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Cerulenin

Cayman Chemical Item Number 10005647

(CAS 17397-89-6)

Cerulenin (CAS 17397-89-6)

See more	Fatty Acids (267) Apoptosis (183) Cancer (606) Nutrition/Diet (64) Obesity (162)

Description

A number of tumor cells and cell lines have been observed to have highly upregulated expression and activity of fatty acid synthase (FAS). Inhibition of FAS by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines,¹ an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FAS pathway.² Cerulenin also leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.³

1 Moche, M., Schneider, G., Edwards, P., et al. Structure of the complex between the antibiotic cerulenin and its target, β-ketoacyl-acyl carrier protein synthase. J Biol Chem 274(10) 6031-6034 (1999).

2 Pizer, E.S., Thupari, J., Han, W.F., et al. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Res 60 213-218 (2000).

3 Loftus, T.M., Jaworsky, D.E., Frehywot, G.L., et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288 2379-2381 (2000).

Formal Name	2R,3S-epoxy-4-oxo-7,10-dodecadienamide
CAS Number	17397-89-6
Molecular Formula	C₁₂H₁₇NO₃
Formula Weight	223.3
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard C/C=C/C/C=C/CCC([C@@H]1[C@H](C(N)=O)O1)=O

Background Reading

Pizer, E.S., Thupari, J., Han, W.F., et al. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Res 60 213-218 (2000).

Moche, M., Schneider, G., Edwards, P., et al. Structure of the complex between the antibiotic cerulenin and its target, β-ketoacyl-acyl carrier protein synthase. J Biol Chem 274(10) 6031-6034 (1999).

Loftus, T.M., Jaworsky, D.E., Frehywot, G.L., et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288 2379-2381 (2000).

Cerulenin is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 mg	$65.00		$0.00
10 mg	$125.00		$0.00
50 mg	$520.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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