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HU-331

Cayman Chemical Item Number 10005673

(CAS 137252-25-6)

HU-331 (CAS 137252-25-6)

See more	Cannabinoids (296) Cancer (606) Forensic Science (306) Neuroscience (654)

Description

The endocannabinoids present a rich system of central cannabinoid (CB₁), peripheral cannabinoid (CB₂), and non-CB receptor-mediated pharmacology that has stimulated research in many fields including memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation.^1,2 HU-331 is a hydroxylquinone cannabidiol analog that exhibits potent antineoplastic activity on a variety of human cancer cell lines.³ It effectively inhibits the growth of human Raji and Jurkat lymphoma cells in vitro with an EC₅₀ of approximately 0.2 µg/ml and an EC₈₀ of 1.56 µg/ml. HU-331 also inhibits the growth of HT-29 colon carcinoma cells, which have been inoculated into nude mice, by more than 50% at a dose of 5 mg/kg.³

1 Pertwee, R.G. Pharmacology of cannabinoid receptor ligands. Curr Med Chem 6 635-664 (1999).

2 Martin, B.R., Mechoulam, R., and Razdan, R.K. Discovery and characterization of endogenous cannabinoids. Life Sci 65 573-595 (1999).

3 Kogan, N.M., Rabinowitz, R., Levi, P., et al. Synthesis and antitumor activity of quinonoid derivatives of cannabinoids. J Med Chem 47 3800-3806 (2004).

Formal Name	3-hydroxy-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-2,5-cyclohexadiene-1,4-dione
CAS Number	137252-25-6
Molecular Formula	C₂₁H₂₈O₃
Formula Weight	328.5
Formulation	A solution in methyl acetate
Purity	≥95%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCC1=CC(=O)C(=C(O)C1=O)[C@@H]1C=C(C)CC[C@H]1C(=C)C

Background Reading

Kogan, N.M., Rabinowitz, R., Levi, P., et al. Synthesis and antitumor activity of quinonoid derivatives of cannabinoids. J Med Chem 47 3800-3806 (2004).

Pertwee, R.G. Pharmacology of cannabinoid receptor ligands. Curr Med Chem 6 635-664 (1999).

Martin, B.R., Mechoulam, R., and Razdan, R.K. Discovery and characterization of endogenous cannabinoids. Life Sci 65 573-595 (1999).

HU-331 is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$49.00		$0.00
5 mg	$221.00		$0.00
10 mg	$392.00		$0.00
25 mg	$858.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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