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NO-Indomethacin Exclusive

Cayman Chemical Item Number 10005705

NCX 2121 (CAS 301838-28-8)

NO-Indomethacin (CAS 301838-28-8)

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Description

NO-indomethacin is a hybrid molecule of indomethacin and a nitric oxide (NO) donor. This drug design combines the anti-inflammatory properties of a non-steroidal anti-inflammatory drug (NSAID) with the gastrointestinal protective effects of NO. Compounds of this class retain their anti-inflammatory and analgesic activity, but have reduced gastrointestinal and kidney toxicity compared to the NSAID alone.1 NO-indomethacin also enhances the cancer chemopreventative activity of indomethacin. NO-indomethacin exhibits an IC50 of 82 µM, compared to >1,000 µM for indomethacin alone, for the inhibition of pancreatic cancer cell (PaCa-2) growth after 24 hours in culture.2

1 Wallace, J.F., Elliott, S.N., Del Soldato, P., et al. Gastrointestinal-sparing anti-inflammatory drugs: The development of nitric oxide-releasing NSAIDs. Drug Dev Res 42 144-149 (1997).

2 Kashfi, K., Ryann, Y., Qiao, L.L., et al. Nitric oxide-donating nonsteroidal anti-inflammatory drugs inhibit the growth of various cultured human cancer cells: Evidence of a tissue type-independent effect. J Pharmacol Exp Ther 303(3) 1273-1282 (2002).

Synonyms
  • NCX 2121
Formal Name N-​acetyl-​D-​cysteine-​1-​(4-​chlorobenzoyl)-​5-​methoxy-​2-​methyl-​1H-​indole-​3-​acetic acid,​ 4-​(nitrooxy)butyl ester
CAS Number 301838-28-8
Molecular Formula C28H30ClN3O9S
Formula Weight 619.1
Formulation A solution in methyl acetate
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C(C1=CC=C(Cl)​C=C1)​N2C3=C(C=C(OC)​C=C3)​C(CC(SC[C@H]​(N(C(C)​=O)​[H]​)​C(OCCCCO[N+]​([O-]​)​=O)​=O)​=O)​=C2C

Background Reading

Wallace, J.F., Elliott, S.N., Del Soldato, P., et al. Gastrointestinal-sparing anti-inflammatory drugs: The development of nitric oxide-releasing NSAIDs. Drug Dev Res 42 144-149 (1997).

Kashfi, K., Ryann, Y., Qiao, L.L., et al. Nitric oxide-donating nonsteroidal anti-inflammatory drugs inhibit the growth of various cultured human cancer cells: Evidence of a tissue type-independent effect. J Pharmacol Exp Ther 303(3) 1273-1282 (2002).

NO-Indomethacin is available in the following screening library:

Size Price Quantity Subtotal
1 mg $16.00 $0.00
5 mg $72.00 $0.00
10 mg $128.00 $0.00
50 mg $560.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Indomethacin

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