Cayman Chemical | (2S)-OMPT

10005707 (2S)-OMPT

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• See more Receptor Biochemistry; Lipids; Phospholipase; Phospholipids; Cell Biology; Signal Transduction

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Lysophosphatidic acid (LPA) is a potent lipid mediator that elicits its effect through four distinct receptors - LPA₁/EDG-2, LPA₂/EDG-4, LPA₃/EDG-7 and LPA₄/GPR23.^1,2 OMPT is a selective agonist of the LPA₃ receptor. It exhibits EC₅₀ values of 68 nM and >6.8 µM for calcium mobilization in LPA₃ and LPA₂-expressing Sf9 cells, respectively.³ The (2S)-OMPT enantiomer is 5- to 20-fold more active than (2R)-OMPT in calcium release assays in both LPA₃-transfected Sf9 and rat hepatoma Rh7777 cells.⁴

1 Chun, J., Goetzl, E.J., Hla, T., et al. International union of pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol Rev 54 265-269 (2002).

2 Niu, S., Mitchell, D.C., Litman, B.J. Trans fatty acid derived phospholipids show increased membrane cholesterol and reduced receptor activation as compared to their cis analogs. Biochemistry 44 4458-4465 (2005).

3 Hasegawa, Y., Erickson, J.R., Goddard, G.J., et al. Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA₃ receptor. J Biol Chem 278(14) 11962-11969 (2003).

4 Qian, L., Xu, Y., Hasegawa, Y., et al. Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA₃ receptor-selective agonist activity. J Med Chem 46 5575-5578 (2003).

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Pricing updated 2010-03-19.
Prices are subject to change without notice.

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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.