Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday.
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Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.
The endocannabinoids present a rich system of central cannabinoid (CB1), peripheral cannabinoid (CB2), and non-CB receptor-mediated pharmacology that has stimulated research in many fields including memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation.1,2 Docosanoyl ethanolamide is a saturated N-acylethanolamide. Non-CB receptor-mediated pharmacology of the saturated ethanolamides is still being elucidated.3 Other studies indicate they may have a role in the functioning of ion channels.4
1
Pertwee, R.G. Pharmacology of cannabinoid receptor ligands. Curr Med Chem6635-664(1999).
2
Martin, B.R., Mechoulam, R., and Razdan, R.K. Discovery and characterization of endogenous cannabinoids. Life Sci65573-595(1999).
3
Smart, D., Jonsson, K., Vandevoorde, S., et al. “Entourage” effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism.. Br J Pharmacol136452-458(2002).
4
Oz, M., Alptekin, A., Tchugunova, Y., et al. Effects of saturated long-chain N-acylethanolamines on voltage-dependent Ca2+ fluxes in rabbit T-tubule membranes. Arch Biochem Biophys434344-351(2005).
Formal Name
N-(2-hydroxyethyl)-docosanamide
CAS Number
94109-05-4
Molecular Formula
C24H49NO2
Formula Weight
383.7
Formulation
A crystalline solid
Purity
≥98%
Stability
2 years
Storage
-20°C
Shipping
Room temperature
in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CCCCCCCCCCCCCCCCCCCCCC(=O)NCCO
Background Reading
Pertwee, R.G. Pharmacology of cannabinoid receptor ligands. Curr Med Chem6635-664(1999).
Oz, M., Alptekin, A., Tchugunova, Y., et al. Effects of saturated long-chain N-acylethanolamines on voltage-dependent Ca2+ fluxes in rabbit T-tubule membranes. Arch Biochem Biophys434344-351(2005).
Smart, D., Jonsson, K., Vandevoorde, S., et al. “Entourage” effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism.. Br J Pharmacol136452-458(2002).
Martin, B.R., Mechoulam, R., and Razdan, R.K. Discovery and characterization of endogenous cannabinoids. Life Sci65573-595(1999).