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10005836 bis(7)-Tacrine
1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydro-acridine
(CAS 224445-12-9)
bis(7)-Tacrine Workbook Links
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Tacrine is an amino acridine compound that inhibits acetylcholinesterase (AChE), and has been proposed as a clinical treatment for Alzheimer’s disease.1 bis(7)-Tacrine is a tacrine dimer, linked via a 7-carbon alkyl spacer. It inhibits AChE with an IC50 of 0.40 nM, making it more than 1,000 times more potent than tacrine.2 bis(7)-Tacrine also protects against hydrogen peroxide induced apoptosis in rat pheochromocytoma cells.3
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1
Giacobini, E. Cholinesterase inhibitors for Alzheimer’s disease therapy: From tacrine to future applications. Neurochem Int 32 413-419 (1998).
2
Carlier, P.R., Han, Y.F., Chow, E.S.H., et al. Evaluation of short-tether Bis-THA AChE inhibitors. A further test of the dual binding site hypothesis. Bioorg Med Chem 7 351-357 (1999).
3
Hong, W., Carlier, P.R., Wing-Lok, H., et al. Attenuation of scopolamine-induced deficits in navigational memory performance in rats by bis(7)-tacrine, a novel dimeric AChE inhibitor. Acta Pharmacol Sin 20(3) 211-217 (1999).
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Pricing updated 2010-03-14.
Prices are subject to change without notice.
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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.
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