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Pentafluorobenzenesulfonyl fluorescein

Cayman Chemical Item Number 10005983

(CAS 728912-45-6)

Pentafluorobenzenesulfonyl fluorescein (CAS 728912-45-6)

See more	Free Radical Generators (10) Reactive Probes (27) Cancer (606) Oxidative Injury (258)

Description

Reactive oxygen species (ROS) play important roles in the initiation and progression of many disease processes. Most fluorescent probes for ROS detection, such as 2,7-dichlorofluorescein (DCFH), function by an oxidative mechanism and are useful for total oxidant detection but are not selective for hydrogen peroxide specifically.¹ Pentafluorobenzenesulfonyl fluorescein is a fluorescent probe that functions by a nonoxidative mechanism. It fluoresces upon perhydrolysis of the sulfonyl linkage, and is selective for hydrogen peroxide over hydroxyl radical, tert-butyl hydroperoxide, superoxide anion, singlet oxygen, and nitrates. Pentafluorobenzenesulfonyl fluorescein can be used as a probe for hydrogen peroxide in whole cell systems.¹

1 Maeda, H., Fukuyasu, Y., Yoshida, S., et al. Fluorescent probes for hydrogen peroxide based on a non-oxidative mechanism. Angew Chem Int Ed 43 2389-2391 (2004).

Formal Name	6’-hydroxy-3-oxospiro[isobenzofuran-1(3H),9’-[9H]xanthen]-3’-yl ester, pentafluorobenzenesulfonic acid
CAS Number	728912-45-6
Molecular Formula	C₂₆H₁₁F₅O₇S
Formula Weight	562.4
Formulation	A crystalline solid
Purity	>98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard FC1=C(F)C(F)=C(F)C(F)=C1S(OC2=CC=C(C3(OC(C4=CC=CC=C43)=O)C(C=CC(O)=C5)=C5O6)C6=C2)(=O)=O

Background Reading

Maeda, H., Fukuyasu, Y., Yoshida, S., et al. Fluorescent probes for hydrogen peroxide based on a non-oxidative mechanism. Angew Chem Int Ed 43 2389-2391 (2004).

Pentafluorobenzenesulfonyl fluorescein is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$33.00		$0.00
5 mg	$149.00		$0.00
10 mg	$264.00		$0.00
25 mg	$578.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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