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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Hesperetin

Cayman Chemical Item Number 10006084

(CAS 520-33-2)

Hesperetin (CAS 520-33-2)

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Description

The flavones and flavonoids are a widespread group of natural products with a variety of reported beneficial health effects. Flavonoids have been implicated as possible active agents in the dietary benefits of citrus fruits. Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol. Hesperetin reduces the transcription of ACAT-2 mRNA in Hep-G2 cells and reduces ApoB protein synthesis in a dose-dependent manner. The EC50 for these responses is approximately 50 µM.1 Hesperetin also inhibits histamine release from IgE-challenged RBL-2H3 cells, with a potency comparable to the commercial anti-allergy drug azelastine.2

1 Wilcox, L.J., Borradaile, N.M., de Dreu, L.E., et al. Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J Lipid Res 42 725-734 (2001).

2 Lee, N., Choi, S., Park, S., et al. Antiallergic activity of hesperidin is activated by intestinal microflora. Pharmacology 71 174-180 (2004).

Formal Name 2,​3-​dihydro-​5,​7-​dihydroxy-​2-​(3-​hydroxy-​4-​methoxyphenyl)-​4H-​1-​benzopyran-​4-​one
CAS Number 520-33-2
Molecular Formula C16H14O6
Formula Weight 302.3
Formulation A crystalline solid
Purity ≥98%
λmax 204, 288 nm
Stability 2 years
Storage Room temperature
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1ccc(cc1O)​C1CC(=O)​c2c(cc(O)​cc2O)​O1

Background Reading

Wilcox, L.J., Borradaile, N.M., de Dreu, L.E., et al. Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J Lipid Res 42 725-734 (2001).

Lee, N., Choi, S., Park, S., et al. Antiallergic activity of hesperidin is activated by intestinal microflora. Pharmacology 71 174-180 (2004).

Hesperetin is available in the following screening library:

Size Price Quantity Subtotal
25 g $32.00 $0.00
50 g $61.00 $0.00
100 g $115.00 $0.00
500 g $512.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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