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Leelamine

Cayman Chemical Item Number 10006148

Dehydroabietylamine (CAS 1446-61-3)

Leelamine (CAS 1446-61-3)

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Description

Leelamine is a diterpene molecule whose name derives from the Sanskrit word leela which means “play”. It has weak affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 µM.1 Leelamine inhibits pyruvate dehydrogenase kinase (PDK) with an IC50 value of 9.5 µM.2 Derivatives of leelamine exhibit anti-inflammatory activity and show moderate inhibition of phospholipase A2 activity from a variety of sources.3

1 Martin, B.R. Leelamine. (2006 Apr 27).

2 Aicher, T.D., Damon, R.E., Koletar, J., et al. Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK). Bioorg Med Chem Lett 9 2223-2228 (1999).

3 Wilkerson, W., DeLucca, I., Galbraith, W., et al. Antiinflammatory phospholipase-A2 inhibitors. I. Eur J Med Chem 26 667-676 (1991).

Synonyms
  • Dehydroabietylamine
Formal Name 1R,​2,​3,​4,​4aS,​9,​10,​10aR-​octahydro-​1,​4a-​dimethyl-​7-​(1-​methylethyl)-​1-​phenanthrenemethanamine
CAS Number 1446-61-3
Molecular Formula C20H31N
Formula Weight 285.5
Formulation A solution in ethanol
Purity >98%
Stability 1 year
Storage Room temperature
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC(C)​C(C=C1)​=CC2=C1[C@]​3(C)​[C@]​(CC2)​([H]​)​[C@@]​(CN)​(C)​CCC3

Background Reading

Martin, B.R. Leelamine. (2006 Apr 27).

Aicher, T.D., Damon, R.E., Koletar, J., et al. Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK). Bioorg Med Chem Lett 9 2223-2228 (1999).

Wilkerson, W., DeLucca, I., Galbraith, W., et al. Antiinflammatory phospholipase-A2 inhibitors. I. Eur J Med Chem 26 667-676 (1991).

Leelamine is available in the following screening library:

Size Price Quantity Subtotal
5 mg $29.00 $0.00
10 mg $55.00 $0.00
25 mg $131.00 $0.00
50 mg $232.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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