Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…

Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

Silybin

Cayman Chemical Item Number 10006211

Silymarin; Silibinin (CAS 22888-70-6)

Silybin (CAS 22888-70-6)

See more	Free Radical Generators (10) Cancer (666)

Description

Silybin (silibinin) is the major flavonolignan from the extracts of milk thistle seed, Silybum marianum. The whole extract, known as silymarin, has been found to protect the liver from both acute and chronic toxicity and injury. Silybin blocks the production of superoxide in PMA-activated rat Kupffer cells with an EC₅₀ of around 100 µM.¹ Silybin also blocks the synthesis of leukotriene B₄ by these same cells with an IC₅₀ of about 15 µM. Thus, part of the protective effects of silybin could be due to 5-lipoxygenase inhibition.

1 Dehmlow, C., Erhard, J., and de Groot, H. Inhibition of kupffer cell functions as an explanation for the hepatoprotective properties of silibinin. Hepatology 23 749-754 (1996).

Synonyms	Silymarin Silibinin
Formal Name	2-[2R,3R-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2R,3R-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
CAS Number	22888-70-6
Molecular Formula	C₂₅H₂₂O₁₀
Formula Weight	482.4
Formulation	A crystalline solid
Purity	>98%
λ_max	229, 288 nm
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard OCC1Oc2ccc(cc2O[C@@H]1c1ccc(O)c(OC)c1)C1Oc2cc(O)cc(O)c2C(=O)[C@@H]1O

Background Reading

Dehmlow, C., Erhard, J., and de Groot, H. Inhibition of kupffer cell functions as an explanation for the hepatoprotective properties of silibinin. Hepatology 23 749-754 (1996).

Size	Price	Quantity	Subtotal
1 g	$8.00		$0.00
5 g	$36.00		$0.00
10 g	$64.00		$0.00
50 g	$280.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Baicalein

(+)-Catechin (hydrate)

Celastrol

Epigallocatechin Gallate

Genistein

Hesperetin

Quercetin

Show all 7 Hide all but first 3

Downloads

	Download Product Insert 105 Kb PDF
	Download Material Safety Data Sheet (MSDS) 17 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640