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Silybin

Cayman Chemical Item Number 10006211

Silymarin; Silibinin (CAS 22888-70-6)

Silybin (CAS 22888-70-6)

See more	Free Radical Generators (10) Cancer (606)

Description

Silybin (silibinin) is the major flavonolignan from the extracts of milk thistle seed, Silybum marianum. The whole extract, known as silymarin, has been found to protect the liver from both acute and chronic toxicity and injury. Silybin blocks the production of superoxide in PMA-activated rat Kupffer cells with an EC₅₀ of around 100 µM.¹ Silybin also blocks the synthesis of leukotriene B₄ by these same cells with an IC₅₀ of about 15 µM. Thus, part of the protective effects of silybin could be due to 5-lipoxygenase inhibition.

1 Dehmlow, C., Erhard, J., and de Groot, H. Inhibition of kupffer cell functions as an explanation for the hepatoprotective properties of silibinin. Hepatology 23 749-754 (1996).

Synonyms	Silymarin Silibinin
Formal Name	2-[2R,3R-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2R,3R-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
CAS Number	22888-70-6
Molecular Formula	C₂₅H₂₂O₁₀
Formula Weight	482.4
Formulation	A crystalline solid
Purity	>98%
λ_max	229, 288 nm
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard OCC1Oc2ccc(cc2O[C@@H]1c1ccc(O)c(OC)c1)C1Oc2cc(O)cc(O)c2C(=O)[C@@H]1O

Background Reading

Dehmlow, C., Erhard, J., and de Groot, H. Inhibition of kupffer cell functions as an explanation for the hepatoprotective properties of silibinin. Hepatology 23 749-754 (1996).

Size	Price	Quantity	Subtotal
1 g	$8.00		$0.00
5 g	$36.00		$0.00
10 g	$64.00		$0.00
50 g	$280.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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