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AN-7

Cayman Chemical Item Number 10006212

(CAS 691410-93-2)

AN-7 (CAS 691410-93-2)

See more	Antioxidants (62) Endocrinology (335) Oxidative Injury (258)

Description

α-Lipoic acid is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. It is an essential cofactor for decarboxylation reactions of the citric acid cycle and acts as a general antioxidant.¹ AN-7 is a more lipophilic analog of α-lipoic acid with enhanced potency and 1.5-fold increased maximal capacity to stimulate glucose transport into myocytes.² This identifies the analogs of lipoic acid as potential new treatments for diabetes.

1 Biewenga, G.P., Haenen, G.R.M.M., and Bast, A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 29(3) 315-331 (1997).

2 Gruzman, A., Hidmi, A., Katzhendler, J., et al. Synthesis and characterization of new and potent α-lipoic acid derivatives. Bioorg Med Chem 12 1183-1190 (2004).

Formal Name	3-(5-[1,2]dithiolan-3yl-pentanoylamino)-propyl]-amide
CAS Number	691410-93-2
Molecular Formula	C₁₉H₃₄N₂O₂S₄
Formula Weight	450.7
Formulation	A crystalline solid
Purity	>98%
λ_max	331 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(CCCCC1SSCC1)NCCCNC(=O)CCCCC1SSCC1

Background Reading

Gruzman, A., Hidmi, A., Katzhendler, J., et al. Synthesis and characterization of new and potent α-lipoic acid derivatives. Bioorg Med Chem 12 1183-1190 (2004).

Biewenga, G.P., Haenen, G.R.M.M., and Bast, A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 29(3) 315-331 (1997).

Size	Price	Quantity	Subtotal
5 mg	$85.00		$0.00
10 mg	$162.00		$0.00
50 mg	$680.00		$0.00
100 mg	$1,190.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Related Products

Antioxidant Assay Kit

DL-α-Lipoic Acid

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