PPARδ Blocking Peptide

Cayman Chemical Item Number 10006247

PPARβ; Peroxisome Proliferator-activated Receptor δ; NR1C2

Description

Peptide sequence: human PPARδ amino acids 39-54 · To be used in conjunction with Cayman’s PPARδ polyclonal antibody (Catalog No. 101720) to block protein-antibody complex formation during immunochemical analysis of PPARδ.

Synonyms

PPARβ
Peroxisome Proliferator-activated Receptor δ
NR1C2

Formulation

200 µg of peptide in 200 µl TBS, pH7.4, containing 0.1% BSA and 0.02% sodium azide

Purity

>70%

Stability

2 years

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Background Reading

Dreyer, C., Krey, G., Keller, H., et al. Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors. Cell 68 879-887 (1992).

Amri, E., Bonino, F., Ailhaud, G., et al. Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors. J Biol Chem 270 2367-2371 (1995).

Lim, H., and Dey, S.K. PPARδ functions as a prostacyclin receptor in blastocyst implantation. Trends Endocrinol Metab 11(4) 137-142 (2000).

He, T., Chan, T.A., Vogelstein, B., et al. PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 99 335-345 (1999).

Wang, Y., Lee, C., Tiep, S., et al. Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity. Cell 113 159-170 (2003).

Berger, J., Leibowitz, M.D., Doebber, T.W., et al. Novel peroxisome proliferator-activated receptor (PPAR) γ and PPARδ ligands produce distinct biological effects. J Biol Chem 274 6718-6725 (1999).

Willson, T.M., Brown, P.J., Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery. J Med Chem 43(4) 528-550 (2000).

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Subtotal

1 ea

$107.00

$0.00

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