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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

D-NMAPPD Exclusive

Cayman Chemical Item Number 10006305

CAY10466; (1R,2R)-B13 (CAS 35922-06-6)

D-NMAPPD (CAS 35922-06-6)

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Description

Ceramidase acts in normal cells to keep ceramide concentrations low and maintain cell viability. The inhibition of ceramidase in both malignant and non-cancerous cells leads to apoptosis.1,2 D-NMAPPD is a potent ceramidase inhibitor that induces apoptosis in human colorectal cancer, keratinocyte, and melanoma cell lines.3,4 D-NMAPPD produces approximately 50% cell non-viability at 10 µM, and >80% cell death at 100 µM.4

1 Geley, S., Hartmann, B.L., and Kofler, R. Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA. FEBS Lett 400 15-18 (1997).

2 Kolesnick, R. The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J Clin Invest 110(1) 3-8 (2002).

3 Raisova, M., Goltz, G., Bektas, M., et al. Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes. FEBS Lett 516 47-52 (2002).

4 Selzner, M., Bielawska, A., Morse, M.A., et al. Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res 61 1233-1240 (2001).

Synonyms
  • CAY10466
  • (1R,2R)-B13
Formal Name N-​[(1R,​2R)-​2-​hydroxy-​1-​(hydroxymethyl)-​2-​(4-​nitrophenyl)ethyl]-​tetradecanamide
CAS Number 35922-06-6
Molecular Formula C23H38N2O5
Formula Weight 422.6
Formulation A crystalline solid
Purity ≥98%
λmax 202, 275 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC[C@@H]​(N([H]​)​C(CCCCCCCCCCCCC)​=O)​[C@H]​(O)​C1=CC=C([N+]​([O-]​)​=O)​C=C1

Background Reading

Geley, S., Hartmann, B.L., and Kofler, R. Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA. FEBS Lett 400 15-18 (1997).

Kolesnick, R. The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J Clin Invest 110(1) 3-8 (2002).

Selzner, M., Bielawska, A., Morse, M.A., et al. Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res 61 1233-1240 (2001).

Raisova, M., Goltz, G., Bektas, M., et al. Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes. FEBS Lett 516 47-52 (2002).

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D-NMAPPD is available in the following screening library:

Size Price Quantity Subtotal
1 mg $18.00 $0.00
5 mg $81.00 $0.00
10 mg $144.00 $0.00
50 mg $630.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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