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Levonorgestrel

Cayman Chemical Item Number 10006318

Norplant (CAS 797-63-7)

Levonorgestrel (CAS 797-63-7)

See more	Hormone (24) Nuclear Receptors (86) Steroids (37) Endocrinology (335)

Description

Progesterone is a steroid secreted by the corpus luteum and placenta. It is responsible for preparing the uterine lining for implantation of a fertilized ovum and to maintain pregnancy. Levonorgestrel is a synthetic progesterone analog (i.e., a progestin) and the biologically active component of norgestrel, which is a racemic mixture. Levonorgestrel prevents pregnancy by inhibiting ovulation and by causing the cervical mucous to thicken, which makes it harder for sperm to move toward the uterus. Levonorgestrel exhibits approximately three-times higher binding affinity than progesterone for the progesterone receptor.¹ A dose of approximately 60 µg is sufficient to prevent ovulation and a therapeutic dose of 0.15-0.5 mg is used in hormone replacement therapy, which is about 1,000-times lower than the progesterone dose.¹

1 Stanczyk, F.Z. All progestins are not created equal. Steroids 68 879-890 (2003).

Synonyms	Norplant
Formal Name	13-ethyl-17α-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one
CAS Number	797-63-7
Molecular Formula	C₂₁H₂₈O₂
Formula Weight	312.5
Formulation	A crystalline solid
Purity	>95%
λ_max	240 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O[C@@]1(C#C)CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4([H])[C@@]3([H])CC[C@@]21CC)=O

Background Reading

Stanczyk, F.Z. All progestins are not created equal. Steroids 68 879-890 (2003).

Levonorgestrel is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
100 mg	$19.00		$0.00
500 mg	$86.00		$0.00
1 g	$152.00		$0.00
5 g	$665.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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