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Norgestrel

Cayman Chemical Item Number 10006319

Ovrette® (CAS 6533-00-2)

Norgestrel (CAS 6533-00-2)

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Description

Progesterone is a steroid secreted by the corpus luteum and placenta. It is responsible for preparing the uterine lining for implantation of a fertilized ovum and to maintain pregnancy. Norgestrel is a synthetic progesterone analog (i.e., a progestin) used as an oral contraceptive, either alone (sold under the trade name Ovrette®), or in combination with estrogens such as ethinyl estradiol. It is a racemic mixture of which levonorgestrel is the biologically active component. Levonorgestrel prevents pregnancy by inhibiting ovulation and by causing the cervical mucous to thicken, which makes it harder for sperm to move toward the uterus. Levonorgestrel exhibits approximately three-times higher binding affinity than progesterone for the progesterone receptor.1 A dose of approximately 60 µg is sufficient to prevent ovulation and a therapeutic dose of 0.15-0.5 mg is used in hormone replacement therapy, which is about 1,000-times lower than the progesterone dose.1

1 Stanczyk, F.Z. All progestins are not created equal. Steroids 68 879-890 (2003).

Synonyms
  • Ovrette®
Formal Name (±)-​13-​ethyl-​17α-​hydroxy-​18,​19-​dinorpregn-​4-​en-​20-​yn-​3-​one
CAS Number 6533-00-2
Molecular Formula C21H28O2
Formula Weight 312.5
Formulation A crystalline solid
Purity ≥95%
λmax 240 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[C@@]​1(C#C)​CC[C@@]​2([H]​)​[C@]​3([H]​)​CCC4=CC(CCC4[C@@]​3([H]​)​CC[C@@]​21CC)​=O

Background Reading

Stanczyk, F.Z. All progestins are not created equal. Steroids 68 879-890 (2003).

Norgestrel is available in the following screening library:

Size Price Quantity Subtotal
100 mg $19.00 $0.00
500 mg $86.00 $0.00
1 g $152.00 $0.00
5 g $665.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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