Cayman Chemical | Norgestrel | Description • Ovrette® (CAS 6533-00-2)

10006319 Norgestrel

Ovrette^® (CAS 6533-00-2)

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• See more Hormone; Nuclear Receptors; Steroids; Endocrinology

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Progesterone is a steroid secreted by the corpus luteum and placenta. It is responsible for preparing the uterine lining for implantation of a fertilized ovum and to maintain pregnancy. Norgestrel is a synthetic progesterone analog (i.e., a progestin) used as an oral contraceptive, either alone (sold under the trade name Ovrette^®), or in combination with estrogens such as ethinyl estradiol. It is a racemic mixture of which levonorgestrel is the biologically active component. Levonorgestrel prevents pregnancy by inhibiting ovulation and by causing the cervical mucous to thicken, which makes it harder for sperm to move toward the uterus. Levonorgestrel exhibits approximately three-times higher binding affinity than progesterone for the progesterone receptor.¹ A dose of approximately 60 µg is sufficient to prevent ovulation and a therapeutic dose of 0.15-0.5 mg is used in hormone replacement therapy, which is about 1,000-times lower than the progesterone dose.¹

1 Stanczyk, F.Z. All progestins are not created equal. Steroids 68 879-890 (2003).

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Purchase 10006319 Norgestrel

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

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Warning This product is not for human or veterinary use.

Pricing updated 2010-03-19.
Prices are subject to change without notice.

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