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Tibolone

Cayman Chemical Item Number 10006321

Liviella; Livial (CAS 5630-53-5)

Tibolone (CAS 5630-53-5)

See more	Hormone (25) Nuclear Receptors (94) Steroids (38) Bone-Related Research (35) Endocrinology (337)

Description

Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the treatment of osteoporosis.¹ Three major metabolites of tibolone are responsible for its tissue selective mechanism of action. Conversion into 3α- and 3β-hydroxy-tibolone results in estrogenic effects in brain, vagina, and bone. The Δ⁴ isomer has progestrogenic and androgenic effects and does not cause estrogenic stimulation in the endometrium.¹ A two-year longitudinal study indicates that low doses (1.25-2.5 mg) of tibolone effectively relieve climacteric symptoms and prevent loss of bone mass in early postmenopausal women.²

1 Kloosterboer, H.J. Tissue-selectivity: The mechanism of action of tibolone. Maturitas 48 S30-S40 (2004).

2 Gambacciani, M., Ciaponi, M., Cappagli, B., et al. A longitudinal evaluation of the effect of two doses of tibolone on bone density and metabolism in postmenopausal women. Gynecol Endocrinol 18 9-16 (2004).

Synonyms	Liviella Livial
Formal Name	17α-hydroxy-7α-methyl-19-norpregn-5(10)-en-20-yn-3-one
CAS Number	5630-53-5
Molecular Formula	C₂₁H₂₈O₂
Formula Weight	312.5
Formulation	A crystalline solid
Purity	>98%
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O[C@@]1(C#C)CC[C@@]2([H])[C@]([C@]3([H])CC[C@@]21C)([H])[C@H](C)CC4=C3CCC(C4)=O

Background Reading

Kloosterboer, H.J. Tissue-selectivity: The mechanism of action of tibolone. Maturitas 48 S30-S40 (2004).

Gambacciani, M., Ciaponi, M., Cappagli, B., et al. A longitudinal evaluation of the effect of two doses of tibolone on bone density and metabolism in postmenopausal women. Gynecol Endocrinol 18 9-16 (2004).

Tibolone is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
100 mg	$15.00		$0.00
500 mg	$60.00		$0.00
1 g	$90.00		$0.00
5 g	$300.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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