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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Tibolone

Cayman Chemical Item Number 10006321

Liviella; Livial (CAS 5630-53-5)

Tibolone (CAS 5630-53-5)

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Description

Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the treatment of osteoporosis.1 Three major metabolites of tibolone are responsible for its tissue selective mechanism of action. Conversion into 3α- and 3β-hydroxy-tibolone results in estrogenic effects in brain, vagina, and bone. The Δ4 isomer has progestrogenic and androgenic effects and does not cause estrogenic stimulation in the endometrium.1 A two-year longitudinal study indicates that low doses (1.25-2.5 mg) of tibolone effectively relieve climacteric symptoms and prevent loss of bone mass in early postmenopausal women.2

1 Kloosterboer, H.J. Tissue-selectivity: The mechanism of action of tibolone. Maturitas 48 S30-S40 (2004).

2 Gambacciani, M., Ciaponi, M., Cappagli, B., et al. A longitudinal evaluation of the effect of two doses of tibolone on bone density and metabolism in postmenopausal women. Gynecol Endocrinol 18 9-16 (2004).

Synonyms
  • Liviella
  • Livial
Formal Name 17α-​hydroxy-​7α-​methyl-​19-​norpregn-​5(10)-​en-​20-​yn-​3-​one
CAS Number 5630-53-5
Molecular Formula C21H28O2
Formula Weight 312.5
Formulation A crystalline solid
Purity >98%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O[C@@]​1(C#C)​CC[C@@]​2([H]​)​[C@]​([C@]​3([H]​)​CC[C@@]​21C)​([H]​)​[C@H]​(C)​CC4=C3CCC(C4)​=O

Background Reading

Kloosterboer, H.J. Tissue-selectivity: The mechanism of action of tibolone. Maturitas 48 S30-S40 (2004).

Gambacciani, M., Ciaponi, M., Cappagli, B., et al. A longitudinal evaluation of the effect of two doses of tibolone on bone density and metabolism in postmenopausal women. Gynecol Endocrinol 18 9-16 (2004).

Tibolone is available in the following screening library:

Size Price Quantity Subtotal
100 mg $15.00 $0.00
500 mg $60.00 $0.00
1 g $90.00 $0.00
5 g $300.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-10. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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