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EUK 134

Cayman Chemical Item Number 10006329

(CAS 81065-76-1)

EUK 134 (CAS 81065-76-1)

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Description

Synthetic manganese-porphyrin complexes have been documented to act as scavengers for oxidative species such as peroxynitrite, superoxide, and hydrogen peroxide. EUK 134 is a salen-manganese complex that has been modified to increase its catalase activity while retaining SOD activity. EUK 134 consumes hydrogen peroxide with an initial reaction rate of 234 µM/min in vitro.1 EUK 134 is protective in a rat stroke model, employing middle cerebral artery ligation. At 2.5 mg/kg, rats treated with EUK 134 showed reduced infarct volume by more than 80%. EUK 134 at 10 mg/kg also significantly attenuates brain damage in rats following systemic administration of kainic acid.2

1 Baker, K., Marcus, C.B., Huffman, K., et al. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury. J Pharmacol Exp Ther 284(1) 215-221 (1998).

2 Rong, Y., Doctrow, S.R., Tocco, G., et al. EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. Proc Natl Acad Sci USA 96 9897-9902 (1999).

Formal Name chloro[[2,​2'-​[1,​2-​ethanediylbis[(nitrilo-​κN)methylidyne]]bis[6-​methoxyphenolato-​κO]]]-​manganese
CAS Number 81065-76-1
Molecular Formula C18H18ClMnN2O4
Formula Weight 416.7
Formulation A crystalline solid
Purity ≥98%
λmax 234, 328 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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[Mn]​[Mn]​[Mn]​[N]​123(=Cc4cccc(OC)​c4O1)​(Cl)​CC[N]​3=Cc1cccc(OC)​c1O2

Background Reading

Baker, K., Marcus, C.B., Huffman, K., et al. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury. J Pharmacol Exp Ther 284(1) 215-221 (1998).

Rong, Y., Doctrow, S.R., Tocco, G., et al. EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. Proc Natl Acad Sci USA 96 9897-9902 (1999).
Size Price Quantity Subtotal
5 mg $25.00 $0.00
10 mg $48.00 $0.00
50 mg $200.00 $0.00
100 mg $350.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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