Cayman Chemical | 2,3-dinor Thromboxane B1 | Description • 2,3-dinor TXB1

10006330 2,3-dinor Thromboxane B₁

2,3-dinor TXB₁

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• See more Thromboxanes; Inflammation; Vascular Disease

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Thromboxane B₂ (TXB₂) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB₂ and 2,3-dinor TXB₂.¹ In rats and rabbits, 2,3-dinor TXB₁ has been identified as another urinary metabolite of TXB₂.^2,3 However in human urine, only trace amounts of 2,3-dinor TXB₁ have been identified.² In rats, 2,3-dinor TXB₁ is excreted at a much higher rate than 2,3-dinor TXB₂ (19.2 ± 4.9 ng/24 hr and 1.6 ± 0.3 ng/24 hr, respectively).² Therefore, urinary 2,3-dinor TXB₁ is a suitable marker of thromboxane biosynthesis in rats.

1 Ciabattoni, G., Pugliese, F., Davi, G., et al. Fractional conversion of thromboxane B₂ to urinary 11-dehydrothromboxane B₂ in man. Biochim Biophys Acta 992 66-70 (1989).

2 Chiabrando, C., Corada, M., Bachi, A., et al. Urinary excretion of 2,3-dinor-thromboxane B₁, a major metabolite of thromboxane B₂ in the rat. Prostaglandins 47 409-422 (1994).

3 Westlund, P., Kumlin, M., Nordenström, A., et al. Circulating and urinary thromboxane B₂ metabolites in the rabbit: 11-dehydro-thromboxane B₂ as parameter of thromboxane production. Prostaglandins 31(3) 413-443 (1986).

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Pricing updated 2010-03-19.
Prices are subject to change without notice.