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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

2,3-dinor Thromboxane B1

Cayman Chemical Item Number 10006330

2,3-dinor TXB1

2,3-dinor Thromboxane B1

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Description

Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.1 In rats and rabbits, 2,3-dinor TXB1 has been identified as another urinary metabolite of TXB2.2,3 However in human urine, only trace amounts of 2,3-dinor TXB1 have been identified.2 In rats, 2,3-dinor TXB1 is excreted at a much higher rate than 2,3-dinor TXB2 (19.2 ± 4.9 ng/24 hr and 1.6 ± 0.3 ng/24 hr, respectively).2 Therefore, urinary 2,3-dinor TXB1 is a suitable marker of thromboxane biosynthesis in rats.

1 Ciabattoni, G., Pugliese, F., Davi, G., et al. Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in man. Biochim Biophys Acta 992 66-70 (1989).

2 Chiabrando, C., Corada, M., Bachi, A., et al. Urinary excretion of 2,3-dinor-thromboxane B1, a major metabolite of thromboxane B2 in the rat. Prostaglandins 47 409-422 (1994).

3 Westlund, P., Kumlin, M., Nordenström, A., et al. Circulating and urinary thromboxane B2 metabolites in the rabbit: 11-dehydro-thromboxane B2 as parameter of thromboxane production. Prostaglandins 31(3) 413-443 (1986).

Synonyms
  • 2,3-dinor TXB1
Formal Name 9α,​11,​15S-​trihydroxy-​2,​3-​dinor-​thromba-​13E-​en-​1-​oic acid
Molecular Formula C18H32O6
Formula Weight 344.4
Formulation A solution in methyl acetate
Purity >98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
O[C@@H]​1[C@H]​(CCCCC(O)​=O)​[C@@H]​(/C=C/[C@@H]​(O)​CCCCC)​OC(O)​C1

Background Reading

Ciabattoni, G., Pugliese, F., Davi, G., et al. Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in man. Biochim Biophys Acta 992 66-70 (1989).

Chiabrando, C., Corada, M., Bachi, A., et al. Urinary excretion of 2,3-dinor-thromboxane B1, a major metabolite of thromboxane B2 in the rat. Prostaglandins 47 409-422 (1994).

Westlund, P., Kumlin, M., Nordenström, A., et al. Circulating and urinary thromboxane B2 metabolites in the rabbit: 11-dehydro-thromboxane B2 as parameter of thromboxane production. Prostaglandins 31(3) 413-443 (1986).

2,3-dinor Thromboxane B1 is available in the following screening library:

Size Price Quantity Subtotal
25 µg $86.00 $0.00
50 µg $163.00 $0.00
100 µg $310.00 $0.00
1 mg $2,408.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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