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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

PDM 11 Exclusive

Cayman Chemical Item Number 10006341

PDM 11

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Description

The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar.1 PDM 11 is structurally very similar to several resveratrol analogs which act as a potent and selective AhR antagonists and agonists.2 One of these compounds, which contains fluorine in place of the 4'-chlorine of PDM11, acts as a AhR antagonist with a Ki of approximately 3 nM.2 This fluorine-containing compound is inactive as a ligand for the estrogen receptor even at 100 µM. As AhR knockout mice are insensitive to the carcinogenic effects of classical AhR ligands, antagonists of AhR could potentially serve as therapeutic agents for the treatment for dioxin and other aryl hydrocarbon poisonings.

1 Denison, M.S., and Nagy, S.R. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.. Annu Rev Pharmacol Toxicol 43 309-334 (2003).

2 de Medina, P., Casper, R., Savouret, J., et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem 48 287-291 (2005).

Formal Name (E)-​5-​[2-​(4-​chlorophenyl)ethenyl]-​1,​3-​dimethoxyphenyl
Molecular Formula C16H15ClO2
Formula Weight 274.7
Formulation A crystalline solid
Purity >98%
λmax 213, 303 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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ClC(C=C1)​=CC=C1/C=C/C2=CC(OC)​=CC(OC)​=C2

Background Reading

de Medina, P., Casper, R., Savouret, J., et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem 48 287-291 (2005).

Denison, M.S., and Nagy, S.R. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.. Annu Rev Pharmacol Toxicol 43 309-334 (2003).

PDM 11 is available in the following screening library:

Size Price Quantity Subtotal
10 mg $20.00 $0.00
25 mg $48.00 $0.00
50 mg $90.00 $0.00
100 mg $160.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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