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PDM 2 Exclusive

Cayman Chemical Item Number 10006342

(CAS 688348-25-6)

PDM 2 (CAS 688348-25-6)

See more	Free Radical (8) Cancer (666) Oxidative Injury (291)

Description

The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar.¹ PDM 2 is an analog of resveratrol acting as a potent and selective AhR antagonist, with a K_i of 1.2 nM.² PDM 2 is inactive as a ligand for the estrogen receptor even at 100 µM. As AhR knockout mice are insensitive to the carcinogenic effects of classical AhR ligands, PDM 2 is a potential therapeutic for the treatment for dioxin and other aryl hydrocarbon poisonings.

1 Denison, M.S., and Nagy, S.R. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.. Annu Rev Pharmacol Toxicol 43 309-334 (2003).

2 de Medina, P., Casper, R., Savouret, J., et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem 48 287-291 (2005).

Formal Name	1,3-dichloro-5-[(1E)-2-(4-chlorophenyl)ethenyl]-benzene
CAS Number	688348-25-6
Molecular Formula	C₁₄H₉Cl₃
Formula Weight	283.6
Formulation	A crystalline solid
Purity	>98%
λ_max	214, 302, 313 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard Clc1ccc(cc1)\C=C/c1cc(Cl)cc(Cl)c1

Background Reading

Denison, M.S., and Nagy, S.R. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.. Annu Rev Pharmacol Toxicol 43 309-334 (2003).

de Medina, P., Casper, R., Savouret, J., et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem 48 287-291 (2005).

PDM 2 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
10 mg	$33.00		$0.00
50 mg	$149.00		$0.00
100 mg	$264.00		$0.00
500 mg	$1,155.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

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