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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

PDM 2 Exclusive

Cayman Chemical Item Number 10006342

(CAS 688348-25-6)

PDM 2 (CAS 688348-25-6)

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Description

The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar.1 PDM 2 is an analog of resveratrol acting as a potent and selective AhR antagonist, with a Ki of 1.2 nM.2 PDM 2 is inactive as a ligand for the estrogen receptor even at 100 µM. As AhR knockout mice are insensitive to the carcinogenic effects of classical AhR ligands, PDM 2 is a potential therapeutic for the treatment for dioxin and other aryl hydrocarbon poisonings.

1 Denison, M.S., and Nagy, S.R. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.. Annu Rev Pharmacol Toxicol 43 309-334 (2003).

2 de Medina, P., Casper, R., Savouret, J., et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem 48 287-291 (2005).

Formal Name 1,​3-​dichloro-​5-​[(1E)-​2-​(4-​chlorophenyl)ethenyl]-​benzene
CAS Number 688348-25-6
Molecular Formula C14H9Cl3
Formula Weight 283.6
Formulation A crystalline solid
Purity >98%
λmax 214, 302, 313 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Clc1ccc(cc1)​\C=C/c1cc(Cl)​cc(Cl)​c1

Background Reading

Denison, M.S., and Nagy, S.R. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.. Annu Rev Pharmacol Toxicol 43 309-334 (2003).

de Medina, P., Casper, R., Savouret, J., et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem 48 287-291 (2005).

PDM 2 is available in the following screening library:

Size Price Quantity Subtotal
10 mg $33.00 $0.00
50 mg $149.00 $0.00
100 mg $264.00 $0.00
500 mg $1,155.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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