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HU-211

Cayman Chemical Item Number 10006350

Dexanabinol (CAS 112924-45-5)

HU-211 (CAS 112924-45-5)

See more	Lipids (176) Forensic Science (369) Neuroscience (725)

Description

The endocannabinoids present a rich system of central cannabinoid (CB₁), peripheral cannabinoid (CB₂), and non-CB receptor-mediated pharmacology that has stimulated research in many fields including memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation.^1,2 HU-211 is a synthetic terpene-based cannabinoid devoid of CB₁ and CB₂ agonist activity, thus lacking the psychomotor responses characteristic of Δ⁹-THC. HU-211 does exhibit the neuroprotective, antioxidant properties of other related compounds like cannabidiol.³ HU-211 also has anti-inflammatory properties derived through inhibition of NF-κB and the resulting decreases in cytokines such as TNFα and IL-6.

1 Pertwee, R.G. Pharmacology of cannabinoid receptor ligands. Curr Med Chem 6 635-664 (1999).

2 Martin, B.R., Mechoulam, R., and Razdan, R.K. Discovery and characterization of endogenous cannabinoids. Life Sci 65 573-595 (1999).

3 Jüttler, E., Potrovita, I., Tarabin, V., et al. The cannabinoid dexanabinol is inhibitor of the nuclear factor-kappa B (NF-κB). Neuropharmacology 47 580-592 (2004).

Synonyms	Dexanabinol
Formal Name	3-(1,1-dimethylheptyl)-6aS,7,10,10aS-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol
CAS Number	112924-45-5
Molecular Formula	C₂₅H₃₈O₃
Formula Weight	386.6
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCC(C)(C)c1cc(O)c2c(c1)OC(C)(C)C1CC=C(CO)C[C@H]21

Background Reading

Pertwee, R.G. Pharmacology of cannabinoid receptor ligands. Curr Med Chem 6 635-664 (1999).

Jüttler, E., Potrovita, I., Tarabin, V., et al. The cannabinoid dexanabinol is inhibitor of the nuclear factor-kappa B (NF-κB). Neuropharmacology 47 580-592 (2004).

Martin, B.R., Mechoulam, R., and Razdan, R.K. Discovery and characterization of endogenous cannabinoids. Life Sci 65 573-595 (1999).

HU-211 is available in the following screening library:

Cannabinoid Agonist Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$36.00		$0.00
5 mg	$162.00		$0.00
10 mg	$288.00		$0.00
25 mg	$630.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Featured Products	Mojo
HU-210 A potent synthetic cannabinoid	45.112620856353
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HU-331 A cannabidiol analog with antiproliferative activity	39.848813177818
(−)-CP 55,940 An agonist of CB1 and CB2	42.173747156320
(+)WIN 55212-2 (mesylate) A potent agonist of CB1 and CB2	59.227790192713
JWH 015 A selective receptor agonist of CB2	63.861233412638
Cannabidiol A neuroprotective phenolic compound from marijuana	31.817340173638

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