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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

HU-211

Cayman Chemical Item Number 10006350

Dexanabinol (CAS 112924-45-5)

HU-211 (CAS 112924-45-5)

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Description

The endocannabinoids present a rich system of central cannabinoid (CB1), peripheral cannabinoid (CB2), and non-CB receptor-mediated pharmacology that has stimulated research in many fields including memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation.1,2 HU-211 is a synthetic terpene-based cannabinoid devoid of CB1 and CB2 agonist activity, thus lacking the psychomotor responses characteristic of Δ9-THC. HU-211 does exhibit the neuroprotective, antioxidant properties of other related compounds like cannabidiol.3 HU-211 also has anti-inflammatory properties derived through inhibition of NF-κB and the resulting decreases in cytokines such as TNFα and IL-6.

1 Pertwee, R.G. Pharmacology of cannabinoid receptor ligands. Curr Med Chem 6 635-664 (1999).

2 Martin, B.R., Mechoulam, R., and Razdan, R.K. Discovery and characterization of endogenous cannabinoids. Life Sci 65 573-595 (1999).

3 Jüttler, E., Potrovita, I., Tarabin, V., et al. The cannabinoid dexanabinol is inhibitor of the nuclear factor-kappa B (NF-κB). Neuropharmacology 47 580-592 (2004).

Synonyms
  • Dexanabinol
Formal Name 3-​(1,​1-​dimethylheptyl)-​6aS,​7,​10,​10aS-​tetrahydro-​1-​hydroxy-​6,​6-​dimethyl-​6H-​dibenzo[b,​d]pyran-​9-​methanol
CAS Number 112924-45-5
Molecular Formula C25H38O3
Formula Weight 386.6
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCCC(C)​(C)​c1cc(O)​c2c(c1)​OC(C)​(C)​C1CC=C(CO)​C[C@H]​21

Background Reading

Pertwee, R.G. Pharmacology of cannabinoid receptor ligands. Curr Med Chem 6 635-664 (1999).

Jüttler, E., Potrovita, I., Tarabin, V., et al. The cannabinoid dexanabinol is inhibitor of the nuclear factor-kappa B (NF-κB). Neuropharmacology 47 580-592 (2004).

Martin, B.R., Mechoulam, R., and Razdan, R.K. Discovery and characterization of endogenous cannabinoids. Life Sci 65 573-595 (1999).

HU-211 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $36.00 $0.00
5 mg $162.00 $0.00
10 mg $288.00 $0.00
25 mg $630.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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