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CAY10462

Cayman Chemical Item Number 10006400

(CAS 502656-68-0)

CAY10462 (CAS 502656-68-0)

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Description

20-HETE is an important metabolite of arachidonic acid in the vasculature, especially in the kidney, where it is synthesized by cytochrome P450 (CYP450) enzymes of the 4A family.1,2 Alkylaryl imidazoles have been shown to inhibit certain CYP450 enzymes, including the CYP4A enzymes associated with 20-HETE synthesis.3 CAY10462 is the hydrochloride salt of CAY10434 and selective inhibitor of the 20-HETE synthase CYP4A11 exhibiting an IC50 of 8.8 nM when tested in human renal microsomes.4 CAY10434 is nearly 200 times less potent as an inhibitor of 1A, 1C, and 3A CYP450 enzymes.

1 Harder, D.R., Lange, A.R., Gebremedhin, D., et al. Cytochrome P450 metabolites of arachidonic acid as intracellular signaling molecules in vascular tissue. J Vasc Res 34 237-243 (1997).

2 Imig, J.D., Zou, A.P., Stec, D.E., et al. Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles.. Am J Physiol 270 R217-R227 (1996).

3 missing reference text

4 Nakamura, T., Kakinuma, H., Umemiya, H., et al. Imidazole derivatives as new potent and selective 20-HETE synthase inhibitor. Bioorg Med Chem Lett 14 333-336 (2004).

Formal Name 6-​[4-​(1H-​imidazol-​1-​yl)phenoxy]-​N,​N-​dimethyl-​1-​hexanamine,​ dihydrochloride
CAS Number 502656-68-0
Molecular Formula C17H25N3O · 2HCl
Formula Weight 360.4
Formulation A crystalline solid
Purity >98%
λmax 202, 246 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CN(C)​CCCCCCOC1=CC=C(N2C=CN=C2)​C=C1.[·2HCl]​

Background Reading

Imig, J.D., Zou, A.P., Stec, D.E., et al. Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles.. Am J Physiol 270 R217-R227 (1996).

Nakamura, T., Kakinuma, H., Umemiya, H., et al. Imidazole derivatives as new potent and selective 20-HETE synthase inhibitor. Bioorg Med Chem Lett 14 333-336 (2004).

Harder, D.R., Lange, A.R., Gebremedhin, D., et al. Cytochrome P450 metabolites of arachidonic acid as intracellular signaling molecules in vascular tissue. J Vasc Res 34 237-243 (1997).

CAY10462 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $19.00 $0.00
5 mg $86.00 $0.00
10 mg $152.00 $0.00
50 mg $665.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

20-HETE
CAY10434
DDMS
HET0016
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