See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

Adipose Triglyceride Lipase Polyclonal Antibody

Cayman Chemical Item Number 10006409

Phospholipase A2ζ; Desnutrin; ATGL

Adipose Triglyceride Lipase Polyclonal Antibody

See more

Description

Antigen: human adipose triglyceride lipase (ATGL) amino acids 382-400 (KRKLGRHLPSRLPEQVELR) · Host: rabbit · Application(s): WB and IHC (paraffin-embedded sections); other applications not tested · Triglycerides are the most efficient form of energy storage in mammalian adipose tissue during times of caloric excess. ATGL is one of the key enzymes involved in the mobilization of fatty acids from triglyceride stores in adipose tissue, catalyzing the conversion of triacylglycerols to diacylglycerols.1 Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity, and thus may be a potential drug target for the diabetic pathology.1 ATGL mRNA is detected in a wide range of tissues including adipose, lung, skeletal muscle, testis, heart, brain, and kidney, with adipose tissue expressing the highest level.2 Human ATGL is 504 amino acids in length with an estimated molecular weight of 55.2 kDa. Cayman’s ATGL polyclonal antibody detects the enzyme at 56 kDa by western blot from tissues and cells such as brown fat, liver, mouse macrophages, and Hep-G2 cells.

1 Zimmermann, R., Strauss, J.G., Haemmerle, G., et al. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306 1383-1386 (2004).

2 Villena, J.A., Roy, S., Sarkadi-Nagy, E., et al. Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids. Ectopic expression of desnutrin increases triglyceride hydrolysis. J Biol Chem 279(45) 47066-47075 (2004).

Synonyms
  • Phospholipase A2ζ
  • Desnutrin
  • ATGL
Formulation Peptide affinity-purified IgG, lyophilized from TBS pH 7.4
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Human ATGL +
Mouse ATGL +
Rat ATGL +

Background Reading

Zimmermann, R., Strauss, J.G., Haemmerle, G., et al. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306 1383-1386 (2004).

Villena, J.A., Roy, S., Sarkadi-Nagy, E., et al. Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids. Ectopic expression of desnutrin increases triglyceride hydrolysis. J Biol Chem 279(45) 47066-47075 (2004).
Size Price Quantity Subtotal
500 µl $229.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Adipolysis Assay Kit
Adipose Triglyceride Lipase Blocking Peptide
Endothelial Lipase Polyclonal Antibody
Hormone Sensitive Lipase Polyclonal Antibody
PPARα Polyclonal Antibody
PPARγ Polyclonal Antibody
PPARδ Polyclonal Antibody
Show all 7 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?