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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

(±)14(15)-EET-d11

Cayman Chemical Item Number 10006410

(±)14(15)-EpETrE-d11

(±)14(15)-EET-d11

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Description

(±)14(15)-EET-d11 contains 11 deuterium atoms at the 16, 16', 17, 17', 18, 18' ,19, 19' ,20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of (±)14(15)-EET by GC- or LC-MS. (±)14,15-DiHETrE is biosynthesized in rat and rabbit liver microsomes by CYP450.1,2 Dramatic increases in urinary (±)14,15-DiHETrE, a (±)14(15)-EET metabolite, have been documented by GC/MS in pregnancy induced hypertension.3

1 Chacos, N., Falck, J.R., Wixtrom, C., et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem Biophys Res Commun 104 916-922 (1982).

2 Oliw, E.H., Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem 257 3771-3781 (1982).

3 Catella, F., Lawson, J.A., Fitzgerald, D.J., et al. Endogenous biosynthesis of arachidonic acid epoxides in humans: Increased formation in pregnancy-induced hypertension. Proc Natl Acad Sci USA 87 5893-5897 (1990).

Synonyms
  • (±)14(15)-EpETrE-d11
Formal Name (±)14(15)-​epoxy-​5Z,​8Z,​11Z-​eicosatrienoic-​16,​16,​17,​17,​18,​18,​19,​19,​20,​20,​20-​d11 acid
Molecular Formula C20H21D11O3
Formula Weight 331.5
Formulation A solution in ethanol
Purity ≥99% deuterated forms (d1-d11)
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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OC(=O)​CCC/C=C\C/C=C\C/C=C\C[C@@H]​1O[C@@H]​1C([2H]​)​([2H]​)​C([2H]​)​([2H]​)​C([2H]​)​([2H]​)​C([2H]​)​([2H]​)​C([2H]​)​([2H]​)​[2H]​

Background Reading

Oliw, E.H., Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem 257 3771-3781 (1982).

Catella, F., Lawson, J.A., Fitzgerald, D.J., et al. Endogenous biosynthesis of arachidonic acid epoxides in humans: Increased formation in pregnancy-induced hypertension. Proc Natl Acad Sci USA 87 5893-5897 (1990).

Chacos, N., Falck, J.R., Wixtrom, C., et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem Biophys Res Commun 104 916-922 (1982).
Size Price Quantity Subtotal
25 µg $145.00 $0.00
50 µg $276.00 $0.00
100 µg $522.00 $0.00
250 µg $1,160.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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(±)14(15)-EET

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