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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

(±)11(12)-EET-d11 Exclusive

Cayman Chemical Item Number 10006413

(±)11(12)-EpETrE-d11

(±)11(12)-EET-d11

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Description

(±)11(12)-EET-d11 contains 11 deuterium atoms at the 16, 16', 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of (±)11(12)-DiHETrE by GC- or LC-mass spectrometry. (±)11(12)-EET is biosynthesized from arachidonic acid in rat and rabbit liver microsomes by CYP450.1,2 (±)11(12)-EET has been shown, along with (±)8(9)-EET, to play a role in the recovery of depleted Ca2+ pools in cultured smooth muscle cells.3

1 Chacos, N., Falck, J.R., Wixtrom, C., et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem Biophys Res Commun 104 916-922 (1982).

2 Oliw, E.H., Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem 257 3771-3781 (1982).

3 Graber, M.N., Alfonso, A., and Gill, D.L. Recovery of Ca2+ pools and growth in Ca2+ pool-depleted cells is mediated by specific epoxyeicosatrienoic acids derived from arachidonic acid. J Biol Chem 272 29546-29553 (1997).

Synonyms
  • (±)11(12)-EpETrE-d11
Formal Name (±)11(12)-​epoxy-​5Z,​8Z,​14Z-​eicosatrienoic-​16,​16,​17,​17,​18,​18,​19,​19,​20,​20,​20 acid
Molecular Formula C20H21D11O3
Formula Weight 331.5
Formulation A solution in ethanol
Purity ≥99% deuterated forms (d1-d11)
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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OC(=O)​CCC/C=C\C/C=C\C[C@@H]​1O[C@@H]​1C/C=C\C([2H]​)​([2H]​)​C([2H]​)​([2H]​)​C([2H]​)​([2H]​)​C([2H]​)​([2H]​)​C([2H]​)​([2H]​)​[2H]​

Background Reading

Chacos, N., Falck, J.R., Wixtrom, C., et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem Biophys Res Commun 104 916-922 (1982).

Oliw, E.H., Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem 257 3771-3781 (1982).

Graber, M.N., Alfonso, A., and Gill, D.L. Recovery of Ca2+ pools and growth in Ca2+ pool-depleted cells is mediated by specific epoxyeicosatrienoic acids derived from arachidonic acid. J Biol Chem 272 29546-29553 (1997).
Size Price Quantity Subtotal
10 µg $132.00 $0.00
25 µg $314.00 $0.00
50 µg $594.00 $0.00
100 µg $1,056.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

(±)11(12)-EET
(±)11(12)-EET Ethanolamide
(±)11(12)-EET methyl ester

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