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Berberine

Cayman Chemical Item Number 10006427

Umbellatine; BBR (CAS 633-65-8)

Berberine (CAS 633-65-8)

See more	Atherosclerosis (323) Endocrinology (335) Metabolism (139)

Description

Berberine is a widely distributed berberidaceaen alkaloid that has been employed in traditional medicine as an antiprotozoal and antidiarrheal agent. Berberine reduces total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides in both humans (at 1 g/day) and hamsters fed 50 mg/kg/day along with a high fat diet.¹ Berberine does not act through 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibition, but instead enhances LDL-receptor protein and mRNA levels in hepatocytes. Berberine is therefore a natural product that may help control serum cholesterol without the side effects typical of the statin family of hypocholesterolemic drugs.

1 Kong, W., Wei, J., Abidi, P., et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med 10(12) 1344-1351 (2004).

Synonyms	Umbellatine BBR
Formal Name	5,6-dihydro-9,10-dimethoxy-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, chloride
CAS Number	633-65-8
Molecular Formula	C₂₀H₁₈ClNO₄
Formula Weight	371.8
Formulation	A crystalline solid
Purity	>95%
λ_max	230, 266, 348, 431 nm
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard COC1=C2C(C=C3[N+](CCC4=C3C=C5C(OCO5)=C4)=C2)=CC=C1OC.[Cl-]

Background Reading

Kong, W., Wei, J., Abidi, P., et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med 10(12) 1344-1351 (2004).

Size	Price	Quantity	Subtotal
1 g	$6.00		$0.00
5 g	$27.00		$0.00
10 g	$48.00		$0.00
25 g	$105.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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