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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

SEW2871

Cayman Chemical Item Number 10006440

(CAS 256414-75-2)

SEW2871 (CAS 256414-75-2)

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Description

Sphingosine-1-phosphate receptor 1 (S1P1) is one of five high affinity G protein-coupled S1P receptors which mediate a variety of effects including lymphocyte recirculation in the blood.1 Non-selective S1P receptor agonists, such as FTY720, produce clinical immunosuppression useful for preventing transplant rejection and treating autoimmune diseases. However, they also cause bradycardia by activating S1P3, the receptor responsible for regulation of heart rate.2 SEW2871 is a selective S1P1 receptor agonist in both human and mouse that is not active at the S1P2-5 receptors. SEW2871, therefore, suppresses the immune response by decreasing the number of lymphocytes circulating in blood without causing bradycardia.2

1 Kluk, M.J., and Hla, T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochim Biophys Acta 1582 72-80 (2002).

2 Sanna, M.G., Liao, J., Jo, E., et al. Sphingosine 1-phosphate (S1P) receptor subtypes SIP1 and SIP3, respectively, regulate lymphocyte recirculation and heart rate. J Biol Chem 279(14) 13839-13848 (2004).

Formal Name 5-​[4-​phenyl-​5-​(trifluoromethyl)-​2-​thienyl]-​3-​[3-​(trifluoromethyl)phenyl]-​1,​2,​4-​oxadiazole
CAS Number 256414-75-2
Molecular Formula C20H10F6N2OS
Formula Weight 440.4
Formulation A crystalline solid
Purity >98%
λmax 242, 273 nm
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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FC(F)​(F)​c1cccc(c1)​c1noc(n1)​c1cc(c2ccccc2)​c(s1)​C(F)​(F)​F

Background Reading

Sanna, M.G., Liao, J., Jo, E., et al. Sphingosine 1-phosphate (S1P) receptor subtypes SIP1 and SIP3, respectively, regulate lymphocyte recirculation and heart rate. J Biol Chem 279(14) 13839-13848 (2004).

Kluk, M.J., and Hla, T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochim Biophys Acta 1582 72-80 (2002).

SEW2871 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $9.00 $0.00
10 mg $17.00 $0.00
25 mg $41.00 $0.00
50 mg $72.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-10. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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