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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

CAY10486

Cayman Chemical Item Number 10006452

4-Hydroxycinnamic acid (L-phenylalanine methyl ester) amide (CAS 615264-52-3)

CAY10486 (CAS 615264-52-3)

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Description

Acyl-Coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis.1,2 CAY10486 inhibits human ACAT-1 and ACAT-2 equally with an IC50 of approximately 60 µM.3 It also inhibits copper-mediated oxidation of low density lipoproteins by about 28% at a concentration of 3 µM.3

1 Rudel, L.L., Lee, R.G., and Cockman, T.L. Acyl coenzyme A: Cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis. Curr Opin Lipidol 12 121-127 (2001).

2 Lee, R.G., Willingham, M.C., Davis, M.A., et al. Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates. J Lipid Res 41 1991-2001 (2000).

3 Lee, S., Han, J., Kim, H., et al. Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA: Cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size. Bioorg Med Chem Lett 14 4677-4681 (2004).

Synonyms
  • 4-Hydroxycinnamic acid (L-phenylalanine methyl ester) amide
Formal Name N-​[3-​(4-​hydroxyphenyl)-​1-​oxo-​2-​propenyl]-​L-​phenylalanine,​ methyl ester
CAS Number 615264-52-3
Molecular Formula C19H19NO4
Formula Weight 325.4
Formulation A crystalline solid
Purity >98%
λmax 210, 226, 311 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C(N[C@@H]​(CC1=CC=CC=C1)​C(OC)​=O)​/C=C/C2=CC=C(O)​C=C2

Background Reading

Rudel, L.L., Lee, R.G., and Cockman, T.L. Acyl coenzyme A: Cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis. Curr Opin Lipidol 12 121-127 (2001).

Lee, R.G., Willingham, M.C., Davis, M.A., et al. Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates. J Lipid Res 41 1991-2001 (2000).

Lee, S., Han, J., Kim, H., et al. Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA: Cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size. Bioorg Med Chem Lett 14 4677-4681 (2004).

CAY10486 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $22.00 $0.00
10 mg $42.00 $0.00
50 mg $176.00 $0.00
500 mg $1,320.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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