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10006486 Ethynyl Estradiol
(CAS 57-63-6)
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Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major estrogen secreted by the premenopausal ovary.1 Ethynyl estradiol is a synthetic analog of estradiol used commonly as an oral contraceptive, often in combination with a progestin such as norgestrel/levonorgestrel or desogestrel. Efficacy of oral administration of ethynyl estradiol is facilitated by the ethynyl substitution at the C-17 position, which inhibits first pass hepatic metabolism. Ethynyl estradiol is also rapidly and almost completely absorbed from the gastrointestinal tract.2
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1
Gruber, C.J., Tschugguel, W., Schneeberger, C., et al. Production and actions of estrogens. N Engl J Med 346(5) 340-352 (2002).
2
Coelingh Bennink, H.J.T. Are all estrogens the same?. Maturitas 47 269-275 (2003).
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Pricing updated 2010-03-16.
Prices are subject to change without notice.
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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.
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