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CAY10465 Exclusive

Cayman Chemical Item Number 10006546

(CAS 688348-33-6)

CAY10465 (CAS 688348-33-6)

See more	Free Radical (8) Nuclear Receptors (86) Cancer (606) Oxidative Injury (258)

Description

The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar.¹ CAY10465 is an analog of resveratrol acting as a potent and selective AhR agonist, with a K_i of 0.2 nM.² CAY10465 is inactive as a ligand for the estrogen receptor even at 100 µM.

1 Denison, M.S., and Nagy, S.R. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.. Annu Rev Pharmacol Toxicol 43 309-334 (2003).

2 de Medina, P., Casper, R., Savouret, J., et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem 48 287-291 (2005).

Formal Name	1,3-dichloro-5-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-benzene
CAS Number	688348-33-6
Molecular Formula	C₁₅H₉Cl₂F₃
Formula Weight	317.1
Formulation	A crystalline solid
Purity	>98%
λ_max	211, 229, 245, 298, 309 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard Clc1cc(/C=C\c2ccc(cc2)C(F)(F)F)cc(Cl)c1

Background Reading

Denison, M.S., and Nagy, S.R. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.. Annu Rev Pharmacol Toxicol 43 309-334 (2003).

de Medina, P., Casper, R., Savouret, J., et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem 48 287-291 (2005).

CAY10465 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$17.00		$0.00
5 mg	$77.00		$0.00
10 mg	$136.00		$0.00
50 mg	$595.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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