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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Latanoprost-d4

Cayman Chemical Item Number 10006556

17-phenyl-13,14-dihydro trinor Prostaglandin F2α-d4 isopropyl ester

Latanoprost-d4

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Description

Latanoprost-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of latanoprost by GC- or LC-mass spectrometry. Latanoprost is the isopropyl ester of 17-phenyl-13,14-dihydro prostaglandin F2α. It is a prodrug form of the free acid, which is a potent agonist of the FP receptor in the eye. Latanoprost reduces intraocular pressure in glaucoma patients with few side effects.1,2,3 The EC50 value of latanoprost for (free acid) for FP receptors is 3.6 nM.4

1 Lindén, C., Nuija, E., and Alm, A. Effects on IOP restoration and blood-aqueous barrier after long term treatment with latanoprost in open angle glaucoma and ocular hypertension. Br J Ophthalmol 81 370-372 (1997).

2 Camras, C.B., Alm, A., Watson, P., et al. Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Ophthalmology 103 1916-1924 (1996).

3 Alm, A., Villumsen, J., Törnquist, P., et al. Intraocular pressure-reducing effect of PhXA41 in patients with increased eye pressure. A one-month study. Ophthalmology 100 1312-1317 (1993).

4 Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs Future 17 691-704 (1992).

Synonyms
  • 17-phenyl-13,14-dihydro trinor Prostaglandin F2α-d4 isopropyl ester
Formal Name 9α,​11α,​15R-​trihydroxy-​17-​phenyl-​18,​19,​20-​trinor-​prost-​5Z-​en-​1-​oic-​3,​3',​4,​4'-​d4 acid,​ isopropyl ester
Molecular Formula C26H36D4O5
Formula Weight 436.6
Formulation A solution in methyl acetate
Purity ≥99% deuterated product
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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OC(CCc1ccccc1)​CC[C@H]​1C(O)​CC(O)​C1C/C=C\CCCC(=O)​OC(C)​C

Background Reading

Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs Future 17 691-704 (1992).

Lindén, C., Nuija, E., and Alm, A. Effects on IOP restoration and blood-aqueous barrier after long term treatment with latanoprost in open angle glaucoma and ocular hypertension. Br J Ophthalmol 81 370-372 (1997).

Alm, A., Villumsen, J., Törnquist, P., et al. Intraocular pressure-reducing effect of PhXA41 in patients with increased eye pressure. A one-month study. Ophthalmology 100 1312-1317 (1993).

Camras, C.B., Alm, A., Watson, P., et al. Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Ophthalmology 103 1916-1924 (1996).

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Size Price Quantity Subtotal
50 µg $33.00 $0.00
100 µg $63.00 $0.00
500 µg $264.00 $0.00
5 mg $1,980.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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