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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

γ-Linolenic Acid methyl ester

Cayman Chemical Item Number 10006579

γ-Linolenic Acid methyl ester; Methyl GLA; Methyl γ-Linolenate (CAS 16326-32-2)

γ-Linolenic Acid methyl ester (CAS 16326-32-2)

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Description

Polyunsaturated fatty acids (PUFAs) are essential nutrients that show distinct deficiency syndromes when not present in adequate amounts in the diet.1,2 γ-Linolenic Acid methyl ester (Methyl GLA) is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets and dietary supplements. GLA is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak leukotriene B4 (LTB4) receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM.3 GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.3

1 Simopoulos, A.P. Omega-3 Fatty acids in health and disease and in growth and development. Am J Clin Nutr 54 438-463 (1991).

2 Holman, R.T. Control of polyunsaturated acids in tissue lipids. J Am Coll Cardiol 5 183-211 (1986).

3 Yagaloff, K.A., Franco, L., Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins Leukot Essent Fatty Acids 52 293-297 (1995).

Synonyms
  • γ-Linolenic Acid methyl ester
  • Methyl GLA
  • Methyl γ-Linolenate
Formal Name 6Z,​9Z,​12Z-​octadecatrienoic acid,​ methyl ester
CAS Number 16326-32-2
Molecular Formula C19H32O2
Formula Weight 292.5
Formulation A solution in ethanol
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C/C=C\C/C=C\CCCCC(OC)​=O

Background Reading

Simopoulos, A.P. Omega-3 Fatty acids in health and disease and in growth and development. Am J Clin Nutr 54 438-463 (1991).

Yagaloff, K.A., Franco, L., Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins Leukot Essent Fatty Acids 52 293-297 (1995).

Holman, R.T. Control of polyunsaturated acids in tissue lipids. J Am Coll Cardiol 5 183-211 (1986).

γ-Linolenic Acid methyl ester is available in the following screening library:

Size Price Quantity Subtotal
50 mg $20.00 $0.00
100 mg $38.00 $0.00
250 mg $90.00 $0.00
1 g $280.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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