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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

CB1 Receptor (C-Term) Blocking Peptide

Cayman Chemical Item Number 10006591

Cannabinoid Receptor 1

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Description

Peptide sequence: CB1 receptor (C-Term) amino acids 461-472 · To be used in conjunction with Cayman’s CB1 Receptor (C-Term) polyclonal antibody (Catalog No. 10006590) to block protein-antibody complex formation during immunochemical analysis of CB1 · The CB1 receptor is a G-protein coupled receptor that binds the active component of cannabis, Δ9-tetrahydrocannabinol.1,2 Human and rat CB1 receptors exhibit 97.3% homology at the amino acid level over the complete protein, and 100% homology within the peptide sequence used to make the Cayman CB1 Receptor polyclonal antibody (Catalog No. 10006590).3,4 This peptide exhibits no homology with the CB2 receptor. Based on the amino acid sequence, the CB1 receptor has a molecular weight of approximately 52,800.4 The CB1 receptor and the splice variant CB1a are localized mainly in the brain whereas the CB2 receptor is localized predominantly in peripheral tissues, including the spleen and hematopoietic cells.3,4,5,6

1 Howlett, A.C., Song, C., Berglund, B.A., et al. Characterization of CB1 cannabinoid receptors using receptor peptide fragments and site-directed antibodies. Mol Pharmacol 53 504-510 (1998).

2 McIntosh, H.H., Song, C., and Howlett, A.C. CB1 cannabinoid receptor: Cellular regulation and distribution in N18TG2 neuroblastoma cells. Mol Brain Res 53 163-173 (1998).

3 Gérard, C.M., Mollereau, C., Vassart, G., et al. Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochem J 279 129-134 (1991).

4 Matsuda, L.A., Lolait, S.J., Brownstein, M.J., et al. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346 561-564 (1990).

5 Shire, D., Carillon, C., Kaghad, M., et al. An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. J Biol Chem 270 3726-3731 (1995).

6 Shire, D., Calandra, B., Rinaldi-Carmona, M., et al. Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor. Biochim Biophys Acta 1307 132-136 (1996).

Synonyms
  • Cannabinoid Receptor 1
Formulation 200 µg of peptide in 200 µl TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Howlett, A.C., Song, C., Berglund, B.A., et al. Characterization of CB1 cannabinoid receptors using receptor peptide fragments and site-directed antibodies. Mol Pharmacol 53 504-510 (1998).

Shire, D., Calandra, B., Rinaldi-Carmona, M., et al. Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor. Biochim Biophys Acta 1307 132-136 (1996).

Shire, D., Carillon, C., Kaghad, M., et al. An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. J Biol Chem 270 3726-3731 (1995).

McIntosh, H.H., Song, C., and Howlett, A.C. CB1 cannabinoid receptor: Cellular regulation and distribution in N18TG2 neuroblastoma cells. Mol Brain Res 53 163-173 (1998).

Matsuda, L.A., Lolait, S.J., Brownstein, M.J., et al. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346 561-564 (1990).

Gérard, C.M., Mollereau, C., Vassart, G., et al. Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochem J 279 129-134 (1991).

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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CB1 Receptor (C-Term) Polyclonal Antibody
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CB2 Receptor Blocking Peptide
CB2 Receptor Polyclonal Antibody
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