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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Prostaglandin D Synthase Inhibitor Screening Assay Kit

Cayman Chemical Item Number 10006595

PGDS Inhibitor Screening Assay Kit

Prostaglandin D Synthase Inhibitor Screening Assay Kit

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Description

Prostaglandin D2 (PGD2) is synthesized by two distinct types of prostaglandin D synthase (PGDS), the lipocalin-type (L-PGDS) enzyme and the hematopoietic (H-PGDS) enzyme. PGD2 is produced by H-PGDS in large quantities by allergen-stimulated mast cells and acts as a pro-inflammatory mediator in allergic reactions. Selective inhibition of H-PGDS is therefore being pursued as a drug target for allergy treatment. The Cayman Chemical PGDS Inhibitor Screening Assay Kit is a complete package for the evaluation of PGDS isozyme-specific inhibitors. Each kit includes highly purified H-PGDS and L-PGDS, as well as PGH2 which serves as the enzyme substrate. A complete enzyme immunoassay (EIA) for the direct quantification of PGD2 quantification without prior methoximation is included in the kit.
Synonyms
  • PGDS Inhibitor Screening Assay Kit
Stability 6 months
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
Specificity
Prostaglandin D2 Ethanolamide 3,000%
Prostaglandin F2α 300%
Prostaglandin D2 100%
Prostaglandin J2 17%
11β-Prostaglandin F2α 10.7%
Thromboxane B2 10%
Prostaglandin D1 1%
Prostaglandin D3 1%
Prostaglandin E2 1%
8-iso Prostaglandin F2α 1%
6-keto Prostaglandin F1α 0.6%
2,3-dinor 11β-Prostaglandin F2α 0.2%
12(S)-HHTrE 0.14%
Δ12-Prostaglandin J2 0.07%
Arachidonic Acid <0.01%
tetranor-PGEM <0.01%
tetranor-PGFM <0.01%
13,14-dihydro-15-keto Prostaglandin D2 <0.01%
15-deoxy-Δ12,14-Prostaglandin J2 <0.01%
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Background Reading

Urade, Y., Watanabe, K., and Hayaishi, O. Prostaglandin D, E, and F synthases. J Lipid Mediat Cell Signal 12 257-273 (1995).

Kanaoka, Y., Fujimori, K., Kikuno, R., et al. Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Eur J Biochem 267 3315-3322 (2000).

Kanaoka, Y., Ago, H., Inagaki, E., et al. Cloning and crystal structure of hematopoietic prostaglandin D synthase. Cell 90 1085-1095 (1997).

Urade, Y., Fujimoto, N., Ujihara, M., et al. Biochemical and immunological characterization of rat spleen prostaglandin D synthetase. J Biol Chem 262(8) 3820-3825 (1987).

Jowsey, I.R., Thomson, A.M., Flanagan, J.U., et al. Mammalian class sigma glutathione s-transferases: Catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases. Biochem J 359 507-516 (2001).

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10006595-96WELL
PGDS Screening Assay Prostaglandin D Synthase (hematopoietic-type) 1 ea
PGDS Screening Assay Prostaglandin D Synthase (lipocalin-type) 1 ea
PGDS Screening Assay Glutathione 1 ea
PGDS Screening Assay Dithiothreitol 1 ea
PGDS Screening Assay Prostaglandin H2 1 ea
PGDS Screening Assay Hydrochloric Acid 1 ea
PGDS Screening Assay Iron (II) Chloride 1 ea
PGDS Screening Assay Reaction Buffer 1 ea
Precoated (Goat Anti-Mouse IgG) EIA 96-Well Strip Plate 1 ea
Polysorbate 20 1 ea
Ellman's Reagent 3 × 100 dtn
EIA Buffer Concentrate (10X) 2 × 10 mL
Wash Buffer Concentrate (400X) 5 mL
Prostaglandin D2 Express AChE Tracer 100 dtn
Prostaglandin D2 Express EIA Monoclonal Antibody 100 dtn
Prostaglandin D2 Express EIA Standard 1 ea
Size Price Quantity Subtotal
96 wells $422.00 $0.00
Bulk Contact
Cart Total $0.00

This product is also available to buy in bulk quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

You may be eligible to receive a free sample Prostaglandin D Synthase Inhibitor Screening Assay Kit under the Cayman Challenge program.

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UltraPure Water
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