Cayman Chemical | S1P1 Blocking Peptide | Description • Sphingosine-1-phosphate Receptor 1; S1PR1; EDG-1

10006616 S1P₁ Blocking Peptide

Sphingosine-1-phosphate Receptor 1; S1PR1; EDG-1

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• See more Immunocytochemistry; Immunohistochemistry; Western Blot; Ceramides/Sphingolipids; Cell Biology; Immunology

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Peptide sequence: human sphingosine-1-phosphate receptor 1 (S1P₁) protein amino acids 241-253 (ISKASRSSEKSLA) · To be used in conjunction with Cayman’s S1P₁ polyclonal antibody (Catalog No. 10005228) to block protein-antibody complex formation during immunochemical analysis of S1P₁. · Sphingosine-1-phosphate (S1P) exerts its activity by binding to five distinct G-protein-coupled receptors, S1P₁/EDG-1, S1P₂/EDG-5, S1P₃/EDG-3, S1P₄/EDG-6, and S1P₅/EDG-8.^1,2 S1P₁ primarily couples with pertussis toxin-sensitive G_i/o proteins to mediate S1P-induced cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.^1,2,3 Expression of S1P₁ is abundant in embryological vasculature and ubiquitous in adult cells, suggesting diverse physiological functions of this receptor.² The human and murine S1P₁ have 382 amino acids with an estimated molecular weight of 43 kDa. Glycosylation at the N-terminal extracellular domain may cause the protein to migrate at higher position in SDS-PAGE.⁴ Cayman’s S1P₁ polyclonal antibody detects the receptor at 47 kDa in western blot. The antibody can also be used in immunostaining to study expression patterns of this protein.

1 Takuwa, Y., Takuwa, N., Sugimoto, N. The Edg family G protein-coupled receptors for lysophospholipids: Their signaling properties and biological activities. J Biochem 131 767-771 (2002).

2 Ishii, I., Fukushima, N., Ye, X., et al. Lysophospholipid receptors: Signaling and biology. Annu Rev Biochem 73 321-354 (2004).

3 Kluk, M.J., Hla, T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochim Biophys Acta 1582 72-80 (2002).

4 Kohno, T., Wada, A., Igarashi, Y. N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization. FASEB J 16 983-992 (2002).

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Purchase 10006616 S1P₁ Blocking Peptide

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Warning This product is not for human or veterinary use.

Pricing updated 2010-03-18.
Prices are subject to change without notice.

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