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10006618 5-OxoETE Receptor Blocking Peptide
TG1019; R527
5-OxoETE Receptor Blocking Peptide Workbook Links
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Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.
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Peptide sequence:
human 5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OxoETE) receptor C-terminal amino acids 408-423 (KVQGEVSLEKEGSSQG)
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To be used in conjunction with Cayman’s 5-OxoETE Receptor polyclonal antibody (Catalog No. 100025) to block protein-antibody complex formation during immunochemical analysis of 5-OxoETE. · The 5-OxoETE receptor recognizes eicosatetraenoic acids and polyunsaturated fatty acids including 5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OxoETE), which is the most potent ligand.1 5-OxoETE is a potent stimulator of chemotaxis for eosinophils and neutrophils that mediates its action via a putative G-protein coupled receptor (GPCR).2,3 The receptor couples to Gi/o to inhibit cyclic AMP production and to mobilize intracellular calcium.2,3 Northern blot analysis reveals that the receptor is highly expressed on eosinophils and neutrophils, suggesting a key role in the inflammatory response.3 In addition, the protein can also be detected in tissues such as kidney and liver.2,3
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1
Im, D. Discovery of new G protein-coupled receptors for lipid mediators. J Lipid Res 45 410-418 (2004).
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Hosoi, T., Koguchi, Y., Sugikawa, E., et al. Identification of a novel human eicosanoid receptor coupled to Gi/o. J Biol Chem 277 (35) 31459-31465 (2002).
3
Jones, C.E., Holden, S., Tenaillon, L., et al. Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils. Mol Pharmacol 63(3) 471-477 (2003).
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Purchase 10006618 5-OxoETE Receptor Blocking Peptide
Pricing is for North America only. Other customers should contact a distributor in their region.
This product is also available to buy in bulk quantities.
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for a quote or to purchase.
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Warning This product is not for human or veterinary use.
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Pricing updated 2010-03-19.
Prices are subject to change without notice.
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