Saturated fatty acids are synthesized by both plants and animals from acetyl coenzyme A as a form of long-term energy storage. Lauric acid is a common 12-carbon saturated fat plentiful in coconut and other nut oils. Saturated free fatty acids induce the expression of cyclooxygenase-2, an effect that is significant at 25 µM in RAW 264.7 cells, with lauric acid being the most potent of the C:8-18 fatty acids.1
1
Lee, J.Y., Sohn, K.H., Rhee, S.H., et al. Saturated fatty acids, but not unsaturated fatty acids, induced the expression of cyclooxygenase-2 mediated through toll-like receptor 4. J Biol Chem276(20)16683-16689(2001).
Formal Name
dodecanoic acid
CAS Number
143-07-7
Molecular Formula
C12H24O2
Formula Weight
200.3
Formulation
A crystalline solid
Purity
>98%
Stability
2 years
Storage
-20°C
Shipping
Wet ice
in continental US; may vary elsewhere
SMILES
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CCCCCCCCCCCC(O)=O
Background Reading
Lee, J.Y., Sohn, K.H., Rhee, S.H., et al. Saturated fatty acids, but not unsaturated fatty acids, induced the expression of cyclooxygenase-2 mediated through toll-like receptor 4. J Biol Chem276(20)16683-16689(2001).
Lauric Acid is available in the following screening
libraries: