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Ketoprofen

Cayman Chemical Item Number 10006661

2-(3-benzoylphenyl)propionic Acid; Oruvail; Orudis (CAS 22071-15-4)

Ketoprofen (CAS 22071-15-4)

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Description

Non-steroidal anti-inflammatory drugs (NSAIDs) are inhibitors of cyclooxygenase-1 (COX-1) and/or COX-2, and are widely used to treat inflammation and pain. Ketoprofen is a non-selective NSAID exhibiting IC50 values of 0.5 µM and 2.33 µM for human recombinant COX-1 and COX-2, respectively.1 It is supplied as a racemic mixture. The R-enantiomer is the more active isomer, effectively blocking COX activity without increasing inflammatory cytokine production.2

1 Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta 1209 130-139 (1994).

2 Ghezzi, P., Melillo, G., Meazza, C., et al. Differential contribution of R and S isomers in ketoprofen anti-inflammatory activity: Role of cytokine modulation. J Pharmacol Exp Ther 287 969-974 (1998).

Synonyms
  • 2-(3-benzoylphenyl)propionic Acid
  • Oruvail
  • Orudis
Formal Name 3-​benzoyl-​α-​methyl-​benzeneacetic acid
CAS Number 22071-15-4
Molecular Formula C16H14O3
Formula Weight 254.3
Formulation A crystalline solid
Purity ≥98%
λmax 254 nm
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O=C(C1=CC=CC=C1)​C2=CC=CC(C(C)​C(O)​=O)​=C2

Background Reading

Ghezzi, P., Melillo, G., Meazza, C., et al. Differential contribution of R and S isomers in ketoprofen anti-inflammatory activity: Role of cytokine modulation. J Pharmacol Exp Ther 287 969-974 (1998).

Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta 1209 130-139 (1994).

Ketoprofen is available in the following screening library:

Size Price Quantity Subtotal
1 g $8.00 $0.00
5 g $36.00 $0.00
10 g $64.00 $0.00
25 g $140.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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