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Ketoprofen

Cayman Chemical Item Number 10006661

2-(3-benzoylphenyl)propionic Acid; Oruvail; Orudis (CAS 22071-15-4)

Ketoprofen (CAS 22071-15-4)

See more	Cyclooxygenase (97) Eicosanoids (216) Inhibitors (493) NSAIDS (24)

Description

Non-steroidal anti-inflammatory drugs (NSAIDs) are inhibitors of cyclooxygenase-1 (COX-1) and/or COX-2, and are widely used to treat inflammation and pain. Ketoprofen is a non-selective NSAID exhibiting IC₅₀ values of 0.5 µM and 2.33 µM for human recombinant COX-1 and COX-2, respectively.¹ It is supplied as a racemic mixture. The R-enantiomer is the more active isomer, effectively blocking COX activity without increasing inflammatory cytokine production.²

1 Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta 1209 130-139 (1994).

2 Ghezzi, P., Melillo, G., Meazza, C., et al. Differential contribution of R and S isomers in ketoprofen anti-inflammatory activity: Role of cytokine modulation. J Pharmacol Exp Ther 287 969-974 (1998).

Synonyms	2-(3-benzoylphenyl)propionic Acid Oruvail Orudis
Formal Name	3-benzoyl-α-methyl-benzeneacetic acid
CAS Number	22071-15-4
Molecular Formula	C₁₆H₁₄O₃
Formula Weight	254.3
Formulation	A crystalline solid
Purity	≥98%
λ_max	254 nm
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(C1=CC=CC=C1)C2=CC=CC(C(C)C(O)=O)=C2

Background Reading

Ghezzi, P., Melillo, G., Meazza, C., et al. Differential contribution of R and S isomers in ketoprofen anti-inflammatory activity: Role of cytokine modulation. J Pharmacol Exp Ther 287 969-974 (1998).

Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta 1209 130-139 (1994).

Ketoprofen is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 g	$8.00		$0.00
5 g	$36.00		$0.00
10 g	$64.00		$0.00
25 g	$140.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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