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HEPC

Cayman Chemical Item Number 10006695

2-Hexadecanoylthio-1-Ethylphosphorylcholine (CAS 60793-01-3)

HEPC (CAS 60793-01-3)

See more	Eicosanoids (216) Fatty Acids (272) Lipid Mediators (47) Phospholipase (79)

Description

Thioester analogs of glycerophospholipids, in combination with Ellman’s reagent, are convenient colorimetric substrates for the measurement of phospholipase activity. HEPC is a truncated analog of phosphatidylcholine with the entire sn-1 substituent deleted, and with a hexadecylthioester in the sn-2 position.¹ HEPC is a substrate for Type II phospholipase A₂ (PLA₂) enzymes, such as porcine pancreatic, bee venom, and snake venom PLA₂. The intrinsic biological activity of HEPC has not been actively investigated.

1 Bhat, M.K., Mueller-Harvey, I., Sumner, I.G., et al. Simplified methods for the synthesis of 2-hexadecanoylthio-1-ethylphosphorylcholine and for the determination of phospholipase A₂ activity. Biochem Biophys Acta 1166 244-250 (1993).

Synonyms	2-Hexadecanoylthio-1-Ethylphosphorylcholine
Formal Name	4-oxide-4-hydroxy-N,N,N-trimethyl-9-oxo-3,5-dioxa-8-thia-4-phosphatetracosan-1-aminium, inner salt
CAS Number	60793-01-3
Molecular Formula	C₂₃H₄₈NO₅PS
Formula Weight	481.7
Formulation	A solution in ethanol
Purity	≥95%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCCCCCCCCCCC(SCCOP([O-])(OCC[N+](C)(C)C)=O)=O

Background Reading

Bhat, M.K., Mueller-Harvey, I., Sumner, I.G., et al. Simplified methods for the synthesis of 2-hexadecanoylthio-1-ethylphosphorylcholine and for the determination of phospholipase A₂ activity. Biochem Biophys Acta 1166 244-250 (1993).

HEPC is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 mg	$128.00		$0.00
10 mg	$243.00		$0.00
25 mg	$576.00		$0.00
50 mg	$1,024.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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