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10006734 CAY10470
(CAS 545380-34-5)
CAY10470 Workbook Links
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Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.
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Nuclear factor-κB (NF-κB) is an ubiquitous transcription factor that functions to enhance the transcription of pro-inflammatory cytokines like TNF-α, IL-1β, IL-6, and IL-8.1 CAY10470 is an inhibitor of NF-κB activation with an IC50 of 11 nM in human Jurkat cells. It also inhibits TNFα production from lipopolysaccharide-stimulated murine splenocytes with an IC50 of 7 nM. CAY10470 showed efficacy in vivo by reducing edema formation in carrageenin-induced inflammation of rat hind paw.2
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1
Karin, M., Yamamtoto, Y., Wang, Q.M. The IKK NF-κB system: A treasure trove for drug development. Nature Reviews Drug Discovery 3 17-26 (2004).
2
Tobe, M., Isobe, Y., Tomizawa, H., et al. Discovery of quinazolines as a novel structural class of potent inhibitors of NF-κB activation. Bioorg Med Chem 11 383-391 (2003).
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Purchase 10006734 CAY10470
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Warning This product is not for human or veterinary use.
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Pricing updated 2010-03-19.
Prices are subject to change without notice.
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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.
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