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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

QNZ

Cayman Chemical Item Number 10006734

CAY10470 (CAS 545380-34-5)

QNZ (CAS 545380-34-5)

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Description

Nuclear factor-κB (NF-κB) is an ubiquitous transcription factor that functions to enhance the transcription of pro-inflammatory cytokines like TNF-α, IL-1β, IL-6, and IL-8.1 QNZ is an inhibitor of NF-κB activation with an IC50 of 11 nM in human Jurkat cells. It also inhibits TNFα production from lipopolysaccharide-stimulated mouse splenocytes with an IC50 of 7 nM. QNZ showed efficacy in vivo by reducing edema formation in carrageenin-induced inflammation of rat hind paw.2

1 Karin, M., Yamamtoto, Y., and Wang, Q.M. The IKK NF-κB system: A treasure trove for drug development. Nat Rev Drug Discov 3 17-26 (2004).

2 Tobe, M., Isobe, Y., Tomizawa, H., et al. Discovery of quinazolines as a novel structural class of potent inhibitors of NF-κB activation. Bioorg Med Chem 11 383-391 (2003).

Synonyms
  • CAY10470
Formal Name N4-​[2-​(4-​phenoxyphenyl)ethyl]-​4,​6-​quinazolinediamine
CAS Number 545380-34-5
Molecular Formula C22H20N4O
Formula Weight 356.4
Formulation A crystalline solid
Purity >98%
λmax 231, 294, 358 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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NC1=CC2=C(N=CN=C2NCCC3=CC=C(OC4=CC=CC=C4)​C=C3)​C=C1

Background Reading

Karin, M., Yamamtoto, Y., and Wang, Q.M. The IKK NF-κB system: A treasure trove for drug development. Nat Rev Drug Discov 3 17-26 (2004).

Tobe, M., Isobe, Y., Tomizawa, H., et al. Discovery of quinazolines as a novel structural class of potent inhibitors of NF-κB activation. Bioorg Med Chem 11 383-391 (2003).

QNZ is available in the following screening library:

Size Price Quantity Subtotal
500 µg $15.00 $0.00
1 mg $29.00 $0.00
5 mg $120.00 $0.00
10 mg $210.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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