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Oleic Acid-2,6-diisopropylanilide

Cayman Chemical Item Number 10006782

(CAS 140112-65-8)

Oleic Acid-2,6-diisopropylanilide (CAS 140112-65-8)

See more	Atherosclerosis (325) Endocrinology (337) Metabolism (145)

Description

AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol.¹ Oleic acid-2,6-diisopropylanilide is an inhibitor of ACAT with an IC₅₀ of 7 nM.² When co-administered to rabbits or rats fed a high fat, high cholesterol diet, oleic acid-2,6-diisopropylanilide decreased LDL and elevated HDL levels when administered at 0.05%.

1 Suckling, K.E., and Stange, E.F. Role of acyl-CoA: Cholesterol acyltransferase in cellular cholesterol metabolism. J Lipid Res 26 647-671 (1985).

2 Roth, B.D., Blankley, C.J., Hoefle, M.L., et al. Inhibitors of acyl-CoA: Cholesterol acyltransferase. 1. Identification and structure-activity relationship of a novel series of fatty acid anilide hypocholesterolemic agents. J Med Chem 35 1609-1617 (1992).

Formal Name	N-[2,6-bis(1-methylethyl)phenyl]-9Z-octadecenamide
CAS Number	140112-65-8
Molecular Formula	C₃₀H₅₁NO
Formula Weight	441.7
Formulation	A solution in methyl acetate
Purity	≥98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CC(C)C1=C(N([H])C(CCCCCCC/C=C\CCCCCCCC)=O)C(C(C)C)=CC=C1

Background Reading

Suckling, K.E., and Stange, E.F. Role of acyl-CoA: Cholesterol acyltransferase in cellular cholesterol metabolism. J Lipid Res 26 647-671 (1985).

Roth, B.D., Blankley, C.J., Hoefle, M.L., et al. Inhibitors of acyl-CoA: Cholesterol acyltransferase. 1. Identification and structure-activity relationship of a novel series of fatty acid anilide hypocholesterolemic agents. J Med Chem 35 1609-1617 (1992).

Oleic Acid-2,6-diisopropylanilide is available in the following screening libraries:

Size	Price	Quantity	Subtotal
5 mg	$27.00		$0.00
10 mg	$51.00		$0.00
50 mg	$216.00		$0.00
100 mg	$378.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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TMP-153 New

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