Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Oleic Acid-2,6-diisopropylanilide

Cayman Chemical Item Number 10006782

(CAS 140112-65-8)

Oleic Acid-2,6-diisopropylanilide (CAS 140112-65-8)

See more	Atherosclerosis (323) Endocrinology (335) Metabolism (139)

Description

AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol.¹ Oleic acid-2,6-diisopropylanilide is an inhibitor of ACAT with an IC₅₀ of 7 nM.² When co-administered to rabbits or rats fed a high fat, high cholesterol diet, oleic acid-2,6-diisopropylanilide decreased LDL and elevated HDL levels when administered at 0.05%.

1 Suckling, K.E., and Stange, E.F. Role of acyl-CoA: Cholesterol acyltransferase in cellular cholesterol metabolism. J Lipid Res 26 647-671 (1985).

2 Roth, B.D., Blankley, C.J., Hoefle, M.L., et al. Inhibitors of acyl-CoA: Cholesterol acyltransferase. 1. Identification and structure-activity relationship of a novel series of fatty acid anilide hypocholesterolemic agents. J Med Chem 35 1609-1617 (1992).

Formal Name	N-[2,6-bis(1-methylethyl)phenyl]-9Z-octadecenamide
CAS Number	140112-65-8
Molecular Formula	C₃₀H₅₁NO
Formula Weight	441.7
Formulation	A solution in methyl acetate
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CC(C)C1=C(N([H])C(CCCCCCC/C=C\CCCCCCCC)=O)C(C(C)C)=CC=C1

Background Reading

Suckling, K.E., and Stange, E.F. Role of acyl-CoA: Cholesterol acyltransferase in cellular cholesterol metabolism. J Lipid Res 26 647-671 (1985).

Roth, B.D., Blankley, C.J., Hoefle, M.L., et al. Inhibitors of acyl-CoA: Cholesterol acyltransferase. 1. Identification and structure-activity relationship of a novel series of fatty acid anilide hypocholesterolemic agents. J Med Chem 35 1609-1617 (1992).

Oleic Acid-2,6-diisopropylanilide is available in the following screening libraries:

Size	Price	Quantity	Subtotal
5 mg	$27.00		$0.00
10 mg	$51.00		$0.00
50 mg	$216.00		$0.00
100 mg	$378.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Berberine

Oleic Acid

Oleic Acid-d₁₇

Oleic Acid ethyl ester

Oleyl Anilide

Show all 5 Hide all but first 3

Downloads

	Download Product Insert 122 Kb PDF
	Download Material Safety Data Sheet (MSDS) 18 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640